Köprülü, Tuğba KulÖkten, SalihTekin, ŞabanÇakmak, Osman2020-06-252020-06-252019closedAccess1095-66701099-0461https://doi.org/10.1002/jbt.22260https://hdl.handle.net/20.500.12587/7852Okten, Salih/0000-0001-9656-1803; Kul Koprulu, Tugba/0000-0001-9451-5715Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death.eninfo:eu-repo/semantics/closedAccessapoptosiscancer cellscytotoxic activitynitroquinolinephenylquinolinequinolinesArticle33310.1002/jbt.222602-s2.0-8505675374930431695Q2WOS:000460550900001Q1