Canseven, Ayşe G.Keskil, Zuhal AktunaKeskil, SemihSeyhan, Nesrin2020-06-252020-06-252007closedAccess0955-30021362-3095https://doi.org10.1080/09553000701206676https://hdl.handle.net/20.500.12587/3931Purpose: To investigate whether pre- and post-drug magnetic field (MF) exposure of 50 Hz, 0.2 mT has any significant effect on pentylenetetrazol (PTZ)-induced seizures in mice. Material and methods: MF was generated by a pair of Helmholtz coils. Seizures were induced by PTZ injection intraperitoneally (i.p.) at a dose of 60 mg/kg. A total of 48 locally bred adult female mice 25 - 35 g in weight were used. Latency to seizure, total seizure duration, and mortality were recorded for each mouse. Results: Neither pre- nor post-drug exposure to a 50 Hz, 0.2 mT MF was found to have any effect on PTZ-induced epileptic seizures or mortality rates in mice. Conclusion: The present study failed to provide any support for a therapeutic potential of a 50 Hz, 0.2 mT MF for epilepsy.eninfo:eu-repo/semantics/closedAccess50 Hzextremely low frequency (ELF)magnetic field (MF)epilepsypentylenetetrazol (PTZ)Article83423123510.1080/095530007012066762-s2.0-3394711918817575950Q2WOS:000246068200003Q1