Aydoğdu, AdnanÜnal, ÖmerBaltacı, Saltuk BuğraMenevşe, EsmaMoğulkoç, RasimErdem, Said SamiBüyükinan, Muammer2025-01-212025-01-2120232564-77842564-7040https://doi.org/10.58600/eurjther1760https://search.trdizin.gov.tr/tr/yayin/detay1221458https://hdl.handle.net/20.500.12587/23853Objective: The aim of this study is to investigate the relationship between leptin, nesfatin 1 and NPY hormones and zinc in boys and girls diagnosed with metabolic syndrome and obesity. Methods: This study included a total of 6 groups. Group 1 Boy Control, Group 2 Girl Control, Group 3 Obese Boys, Group 4 Obese Girls, Group 5 Boys with Metabolic Syndrome, Group 2 with Girls with Metabolic Syndrome. Plasma leptin, nesfatin-1, NPY (by ELISA method) and serum zinc (by AA method) levels were determined in blood samples obtained from the subjects. Results: Leptin and zinc levels were significantly higher both in boy and girl patients with metabolic syndrome than in obese and control children. Nesfatin-1 and NPY levels were significantly lower both in girl and boy obese and metabolic syndrome children compared to their control groups. Conclusion: In the current study a significant increase in plasma leptin and serum zinc levels and a significant decrease of plasma nesfatin-1 and NPY levels were observed in boys and girls with metabolic syndrome. The findings of our study show that leptin, nesfatin-1 and NPY levels may be important biomarkers in the assessment of metabolic syndrome risk in both girls and boys.eninfo:eu-repo/semantics/openAccessChildren; metabolic syndrome; obesity; leptin; nesfatin 1; NPY; zincArticle29485686510.58600/eurjther17601221458WOS:001162350300020Q3