Doğru, M. TolgaBasar, M. Murad2020-06-252020-06-252010closedAccess0301-16231573-2584https://doi.org/10.1007/s11255-009-9658-2https://hdl.handle.net/20.500.12587/4677Background We aimed to investigate differences in circadian autonomic changes in patients suffering from hyperlipidemia with and without erectile dysfunction and compared results to control cases. Materials and methods A total of 77 patients (age range: 24-74, mean age: 45.3 +/- 9.3) with uncontrolled hyperlipidemia (total cholesterol > 200 mg/dL and/or LDL > 160 mg/dL despite a regular diet) were enrolled into the study. These patients were divided into two groups according to their International Index of Erectile Function (IIEF-EF) scores as having erectile dysfunction (IIEF-EF < 26) (Group 1) or as having normal erectile function (IIEF-EF >= 26) (Group 2). In addition, the control group comprised 44 healthy men (age range: 20-57, mean age: 44.0 +/- 10.8) (Group 3). Heart rate variability parameters obtained by 24-h Holter monitoring were utilized for the indirect evaluation of autonomic function. Results There were statistically significant differences between the groups with respect to daytime and nocturnal autonomic activity (p < 0.005). Moreover, Group 1 had lower nocturnal parasympathetic and higher nocturnal sympathetic activity compared to the other groups (for nocturnal HFn p(1-2) < 0.001; p(1-3) < 0.001; p(2-3) > 0.05; for nocturnal LFn p(1-2) < 0.001; p(1-3) < 0.001; p(2-3) > 0.05). Conclusion We concluded that hyperlipidemia results in deterioration of autonomic circadian rhythm. Hyperlipidemic patients with erectile dysfunction had diminished nocturnal parasympathetic activities.eninfo:eu-repo/semantics/closedAccessAutonomic nervous systemErectile dysfunctionHyperlipidemiaArticle42358959610.1007/s11255-009-9658-22-s2.0-7854929246519866371Q2WOS:000284910500007Q3