Vural, Altugan CahitOdabas, SedatKorkusuz, PetekSaglam, Atiye Seda YarBilgic, ElifCavusoglu, TarikVargel, Ibrahim2020-06-252020-06-252017Altugan Cahit Vural, Sedat Odabas, Petek Korkusuz, Atiye Seda Yar Sağlam, Elif Bilgiç, Tarık Çavuşoğlu, Erhan Piskin & İbrahim Vargel (2017) Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells, Artificial Cells, Nanomedicine, and Biotechnology, 45:3, 544-550.2169-14012169-141Xhttps://doi.org/10.3109/21691401.2016.1160918https://hdl.handle.net/20.500.12587/7050Odabas, Sedat/0000-0002-7844-7019; KORKUSUZ, PETEK/0000-0002-7553-3915Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.eninfo:eu-repo/semantics/openAccessBone morphogenetic protein-2cranial bone regenerationcritical size defectmesenchymal stem celltransfectionArticle45354455010.3109/21691401.2016.11609182-s2.0-8496139002627002739Q1WOS:000394598300019Q2