Sezen, Saban CemCelik, Ilknur AytekinAydin, Muhammed EnesOzterlemez, Naciye TurkArslan, MustafaErbatur, Meral ErdalKavutcu, Mustafa2021-01-142021-01-142020Sezen, Ş. C., Aytekin Çelik, İ., Aydın, M. E., Türk Özterlemez, N., Arslan, M., Erdal Erbatur, M., & Kavutçu, M. (2020). Effect of Dexmedetomidine on Lung Tissue Lower Extremity Ischemia Reperfusion Injury in Streptozotocin Induced Diabetic Rats. Gazi Medical Journal, 31(3), 358–362.2147-2092https://doi.org/10.12996/gmj.2020.87https://hdl.handle.net/20.500.12587/12865Celik, ilknur Aytekin/0000-0003-0754-680X;Objective: The aim of our study was to investigate the effects of dexmedetomidine on lung tissue in rat's lower extremity after undergoing an ischemia reperfusion (I/R) injury. Material and methods: After obtaining ethical committee approval, 24 Wistar albino rats (200-270 gr) were randomly divided into four groups: (Control (Group C), diabetes-control (Group DC), diabetes I/R (Group DIR), and diabetes-I/R-dexmedetomidine (Group DIRD). In diabetes groups, single-dose (55 mg/kg) streptozotocin was administered intraperitoneally. Rats with a blood glucose level above 250 mg/dl at the 72nd hour were accepted as diabetic. At the end of four weeks, laparotomy was performed in all rats. Nothing else was done in Group C and DC. In Group DIR, ischemia reperfusion was produced via two-hour periods of clamping and subsequent declamping of infra-renal abdominal aorta. In Group DIRD, 100 mu g/kg of dexmedetomidine were administered intraperitoneally. Results: When the groups' lung tissue neutrophil infiltration/aggregation light microscopic findings were compared to each other, a significant difference was observed among the groups (p=0.003). When the groups' lung tissue injury score light microscopic findings were compared, a significant difference was observed among the groups (p=0.001). When groups were compared to each other in terms of lung tissue MDA levels and SOD activities, a significant difference was observed (p=0.002, p=0.018, respectively). Conclusion Our results confirm that dexmedetomidine has protective effects against the lung damage resulting from IR in diabetic rats. However, future studies should be conducted to evaluate these effects.eninfo:eu-repo/semantics/openAccessDexmedetomidineischemia reperfusionlungratArticle31335836210.12996/gmj.2020.872-s2.0-85087126282Q4WOS:000541649000005N/A