Tatar, T.Polat, Y.Comu, F. M.Kartal, H.Arslan, M.Kucuk, A.2020-06-252020-06-252018Tatar T, Polat Y, Comu FM, Kartal H, Arslan M, Kucuk A. Effect of cerium oxide on erythrocyte deformability in rat lower extremity ischemia reperfusion injury. Bratisl Lek Listy. 2018;119(7):441-443.0006-92481336-0345https://doi.org/10.4149/BLL_2018_080https://hdl.handle.net/20.500.12587/7518Arslan, Mustafa/0000-0003-4882-5063; KARTAL, HAKAN/0000-0003-4539-0228BACKGROUND: Cerium oxide is the oxide form of cerium, which has protective effects in ischemia reperfusion (I/R) injury. The purpose of our study was to look into the effects of this rare-earth metal on erythrocyte deformability in rat lower extremity I/R injury model. MATERIALS AND METHODS: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n = 6), cerium oxide group 0.5 mg.kg(-1), intraperitoneal (group CO; n = 6), I/R group (group I/R; n = 6) and I/R group with cerium oxide 0.5 mg.kg(-1) intraperitoneally (group I/R-CO; n = 6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. RESULTS: We obtained similar results from the control and I/R-CO groups (p = 0.158). The results in I/R group were evidently higher than those of the control, CO, and IR-CO groups (p < 0.0001, p < 0.0001, p = 0.001, respectively). CONCLUSION: We detected unfavorable effects of I/R on erythrocyte deformability, which may impair blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that cerium oxide had beneficial effects by reversing undesirable effects of I/R. Further studies with larger volume are required to support our promising results (Fig. 1, Ref. 24). Text in PDF www.elis.sk.eninfo:eu-repo/semantics/openAccesserythrocyte deformabilityischemia reperfusioncerium oxideratArticle119744144310.4149/BLL_2018_0802-s2.0-8505009472130160134Q2WOS:000440978000008Q3