Sapmaz, FerdaneKalkan, Ismail H.Suslu, IncilayDemirci, HuseyinAtasoy, PinarGuliter, Sefa2020-06-252020-06-252015closedAccess1751-29721751-2980https://doi.org/10.1111/1751-2980.12272https://hdl.handle.net/20.500.12587/6078ObjectiveWe aimed to compare the plasma pantoprazole level (PPL) between patients with type 2 diabetes mellitus and non-diabetic patients during Helicobacter pylori (H. pylori) eradication treatment and to explore the role of PPL in predicting the treatment success rates. MethodsThis study included 40 diabetic and 40 non-diabetic treatment-naive H.pylori-infected patients. Bismuth-based standard quadruple treatment for H.pylori eradication was used for 14 days in both groups. PPL was measured using the square-wave voltammetry method. ResultsH.pylori eradication rate (60.0% vs 87.5%, P=0.005) and PPL (0.25 0.03 g/mL vs 0.34 +/- 0.03 g/mL, P < 0.001) was significantly lower in the diabetic group compared with the controls. Patients with treatment failure had lower PPL than those with successful treatment (P<0.001). The receiver operating characteristics curve demonstrated that PPL had a significant predictive value for the outcome of H.pylori eradication. ConclusionType 2 diabetic patients had lower PPL than the non-diabetic controls, which led to their lower H. pylori eradication rates.eninfo:eu-repo/semantics/closedAccesseradicationplasma pantoprazole leveltype 2 diabetes mellitusArticle16953153610.1111/1751-2980.122722-s2.0-8494251420926147605Q2WOS:000362088800007Q3