Atayoglu, Ayten GunerMuluk, Nuray BayarKoca, RahimeCukurova, IbrahimCetinkaya, Erdem AtalayYoruk, OzgurBal, Cengiz2025-01-212025-01-2120240145-56131942-7522https://doi.org/10.1177/01455613241287298https://hdl.handle.net/20.500.12587/25006Objectives: We investigated the effectiveness of different types of nasal irrigation sprays in adult allergic rhinitis (AR) patients. Methods: A total of 1700 patients with AR (866 males and 834 females) were assigned to: Group 1: Hypertonic nasal spray group (n = 600) (Sinomarin (R) hypertonic nasal spray); Group 2: Algae-containing hypertonic nasal spray group (n = 600) (Sinomarin Plus Algae ENT); and Group 3: Isotonic saline nasal spray group (n = 500). All patients underwent an otolaryngological examination, continued their standard AR treatment, and received the assigned nasal spray additionally (1 spray to each nostril, 3 times a day, for 3 weeks). Allergic symptom scores, turbinate examination, total symptom scores, and quality of life (QoL) scores were evaluated during pre- and post-treatment periods. Results: In groups 1 and 2, symptom scores and turbinate color and edema, total symptom scores, and QoL scores increased after treatment (P < .05). In the saline group, there were no significant differences in symptom scores and total symptom scores after treatment; however, improvement was detected in turbinate color and edema values after treatment. QoL scores increased after treatment. When comparing the 3 groups, the total symptom scores of groups 1 and 2 were significantly lower, and the QoL scores of groups 1 and 2 were considerably higher than those of the saline group. There were no significant differences between groups 1 and 2. Conclusion: Algae-containing and hypertonic nasal spray may be added to the standard AR treatment to increase QoL and decrease total symptom scores.eninfo:eu-repo/semantics/openAccessalgae-containing hypertonic nasal spray; hypertonic nasal spray; isotonic saline nasal spray; allergic rhinitis; total symptom scores; quality of life scoresInvestigation of the Effectiveness of Nasal Sprays in Allergic RhinitisArticle1033_SUPPL144S151S10.1177/014556132412872982-s2.0-8520644627439390797Q2WOS:001336370300001N/A