Tursun, SerkanAlpcan, AysegulOzsoy, MetinBadem, Nermin DindarKandur, YasarAcar, Banu Celikel2025-01-212025-01-2120211305-77071305-7693https://doi.org/10.1055/s-0041-1724024https://hdl.handle.net/20.500.12587/24519Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI). Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test. Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.63.2 (range=1-14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 +/- 323 vs. 490 +/- 299 pg/mL, p=0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve=0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI. Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.eninfo:eu-repo/semantics/closedAccessurinary tract infections; biomarker; myeloid cells-1Article16312913310.1055/s-0041-17240242-s2.0-85101864278Q4WOS:000621594600004Q4