Isiklan, NuranHussien, Nizamudin AwelTurk, Mustafa2025-01-212025-01-2120210927-77571873-4359https://doi.org/10.1016/j.colsurfa.2021.126256https://hdl.handle.net/20.500.12587/25514In the present study, we have designed and developed gelatin-decorated magnetic graphene oxide nanoplatform (MGO@GEL) for photothermal therapy and paclitaxel delivery. The surface morphology, chemical structure, magnetic property, and thermal stability of the MGO@GEL nanosheets were investigated using TEM, AFM, FTIR, XRD, BET, VSM, and TGA methods. Paclitaxel (PAC) as a chemotherapy drug, release behavior was performed at two pH levels and showed strong pH dependence. The anticancer efficiency and biocompatibility of the nanosheets were achieved by MTT analysis using MCF-7 cancer cells with and without 808 NIR laser and L-929 fibroblast cells. Furthermore, the pH-sensitive release behavior of the nanosheets demonstrated higher PAC release at pH 5.5 than at pH 7.4. Moreover, cytotoxicity analysis illustrated the MGO@GEL nanosheets are biocompatible while MGO@GEL@PAC nanosheets exhibited high toxicity to kill MCF-7 cells, especially with NIR laser. Based on the obtained results, the developed multifunctional nanostructures may be a promising candidate for chemo-photothermal therapy and drug delivery.eninfo:eu-repo/semantics/closedAccessNano platform; Graphene oxide; Gelatin; Iron oxide; Photothermal therapy; Drug deliveryArticle61610.1016/j.colsurfa.2021.1262562-s2.0-85101343224Q1WOS:000635442100004Q2