Tuncel, AltugAslan, YilmazBasar, M. MuradAtan, Ali2020-06-252020-06-252008Tuncel, A., Aslan, Y., Başar, M. M., Atan, A. (2008). Efficacy of clomipramine, sertraline and terazosin treatments in premature ejaculation. Turkish Journal of Medical Sciences, 38(1), 59 - 64.1300-0144https://hdl.handle.net/20.500.12587/4237ASLAN, YILMAZ/0000-0003-0670-6840Aim: To compare the efficacy of oral domipramine, sertraline and terazosin to placebo in premature ejaculation. Materials and Methods: A total of 90 patients aged from 20 to 58 years were enrolled in this study. Patients were randomized into 4 groups. Group 1 (n: 22) took placebo and served as controls. Group 2 (n: 23) patients took 25 mg clomipramine HCl nightly; Group 3 (n: 20). 50 mg sertraline nightly; and Group 4 (n: 25) 5 mg terazosin nightly. The medications were used for two months. After 8 sexual attempts, the patients' clinical responses were assessed using the patient self-description method. Clinical responses were classified as "no change", "improvement" and "under control". Success was described as improvement + under control. Results: Success rates were 36.3% in Group 1, 91.3% in Group 2, 90% in Group 3 and 76% in Group 4. Although the efficacy of each medical treatment was superior to placebo (P = 0.001), no significant difference in efficacy was found between the medical treatment groups (P = 0.537). Conclusions: Clomipramine, sertraline and terazosin are more efficient than placebo. No significant difference was observed in terms of efficacy among these three medical treatments.eninfo:eu-repo/semantics/openAccesspremature ejaculationtreatmentantidepressantalpha blockerArticle38159642-s2.0-40449102959Q178838WOS:000254179000010N/A