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Central nervous system and skull malformations associated with Bovine Viral Diarrhea Virus in a calf
Atmaca, Hasan Tarik; Dincel, Gungor Cagdas; Kumandas, Ali; Kul, Oguz; Orhan, Ismail Onder (Ankara Univ Press, 2012)In this study, cranial anomalies, hydranencephaly and cerebellar hypoplasia were reported macroscopically, microscopically and immunohistochemically in a calf. A relationship between Bovine Viral Diarrhea Virus infection ... -
Cerebral ischaemia/reperfusion injury could be managed by using tramadol
Akkurt, Ibrahim; Cetin, Cansel; Erdogan, Ahmet Melih; Dincel, Gungor Cagdas; Ceylan, Asli Fahriye; Kisa, Ucler; Bakar, Bulent (Taylor & Francis Ltd, 2018)Objectives: No valid treatment modality that will repair stroke damage and provide neurological recovery has yet been identified in literature. Studies demonstrated that adequate quality of life could be provided if ... -
Characterization of chondrocytes cultured on catechin-loaded alginate-chitosan scaffolds
Turk, Mustafa; Karahan, Siyami; Cinar, Miyase; Kucuk, Sebnem; Dincel, Gungor Cagdas (Informa Healthcare, 2013)Bovine chondrocytes were seeded into scaffolds of a high molecular weight chitosan and alginate with a pore size of 50-350 mu m with or without catechin. In polymerase chain reaction (PCR), unlike type II, collagen type I ... -
Effect of Local and Systemic Dimethylsulfoxide on Peripheral Nerve Repair: A Controlled Randomized Experimental Study
Sanli, Elif; Dincel, Gungor Cagdas; Umay, Ebru (Taylor & Francis Inc, 2019)Introduction: We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except ... -
Effectiveness of the Biophysical Barriers to the Peridural Fibrosis in Rat Laminectomy Model
Akkurt, Ibrahim; Bakar, Bulent; Dincel, Gungor Cagdas; Yildiran, Fatma Azize Budak; Ogden, Mustafa; Nursoy, Egemen; Sari, Elif (Taylor & Francis Inc, 2019)Purpose: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. Aim of the study: Present study was ... -
Effects of DMSO on a rabbit ear hypertrophic scar model: A controlled randomized experimental study
Sari, Elif; Bakar, Bulent; Dincel, Gungor Cagdas; Yildiran, Fatma Azize Budak (Elsevier Sci Ltd, 2017)Dimethyl sulfoxide (DMSO) is an anti-inflammatory, antibacterial, analgesic drug widely used to treat several diseases as reported in the literature. It has a detractive effect on collagen deposition in the abnormal tissue. ... -
Effects of Sulphasalazine in Cerebral Ischemia Reperfusion Injury in Rat
Cetin, Cansel; Erdogan, Ahmet Melih; Dincel, Gungor Cagdas; Bakar, Bulent; Kisa, Ucler (Elsevier Science Inc, 2017)Background. Management of cerebral ischemia/reperfusion (I/R) injury is still difficult process today. Aims of the Study. Aim of present study was to investigate therapeutic properties of sulfasalazine in cerebral transient ... -
eNOS and iNOS trigger apoptosis in the brains of sheep and goats naturally infected with the border disease virus
Dincel, Gungor Cagdas; Kul, Oguz (F Hernandez, 2015)In this study, apoptotic and anti-apoptotic mechanisms and if present, which pathway to trigger the apoptosis in the brains of Border Disease Virus (BDV) infected lambs (n=10) and goat kids (n=5) were investigated. Briefly, ... -
First description of enhanced expression of transforming growth factor-alpha (TGF-alpha) and glia maturation factor-beta (GMF-beta) correlate with severity of neuropathology in border disease virus-infected small ruminants
Dincel, Gungor Cagdas; Kul, Oguz (Academic Press Ltd- Elsevier Science Ltd, 2019)Border disease (BD) is caused by Pestivirus and characterized by severe neuropathology, and histopathologically observed severe hypomyelination. We have previously shown that small ruminants infected with border disease ... -
Immunohistochemical investigation of the damage to and repair of myelin, and astrocyte activity in small ruminants resulting from with natural meningoencephalitic listeriosis
Ozyildiz, Zafer; Dincel, Gungor Cagdas; Terzi, Osman Safa; Ozsoy, Sule Yurdagul; Kul, Oguz (Ankara Univ Press, 2018)Meningoencephalitic listeriosis is a significant bacterial disease in various species. Common characteristics include microabscesses in the brainstem, midbrain and cerebellum. Many aspects of damage to the central nervous ... -
Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik (Wiley, 2016)Toxoplasma gondii (T. gondii) is a protozoan parasite with the potential of causing severe encephalitis among immunocompromised humans and animals. Our previous study showed that T. gondii induces high nitric oxide (NO) ... -
Increased Expressions of ADAMTS-13, Neuronal Nitric Oxide Synthase, and Neurofilament Correlate with Severity of Neuropathology in Border Disease Virus-Infected Small Ruminants
Dincel, Gungor Cagdas; Kul, Oguz (Public Library Science, 2015)Border Disease (BD), caused by Pestivirus from the family Flaviviridae, leads to serious reproductive losses and brain anomalies such as hydranencephaly and cerebellar hypoplasia in aborted fetuses and neonatal lambs. In ... -
The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat
Yuksel, Ulas; Bakar, Bulent; Dincel, Gungor Cagdas; Yildiran, Fatma Azize Budak; Ogden, Mustafa; Kisa, Ucler (Taylor & Francis Inc, 2019)Aim: Today, spinal cord injury (SCI) can be rehabilitated but cannot be treated adequately. This experimental study was conducted to investigate possible beneficial effects of methylprednisolone and parecoxib in treatment ... -
Nitric oxide production increases during Toxoplasma gondii encephalitis in mice
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik (Academic Press Inc Elsevier Science, 2015)Toxoplasma gondii is an intracellular parasite with the potential of causing severe encephalitis among immunocompromised human and animals. The aim of this experimental study was to investigate the immunomodulatory and ... -
Research on the Effects of Levetiracetam in Spinal Cord Injury Model in Rats: An Experimental Study
Nursoy, Egemen; Ogden, Mustafa; Bakar, Bulent; Dincel, Gungor Cagdas; Kisa, Ucler; Ozveren, Mehmet Faik (TAYLOR & FRANCIS INC, 2020)Purpose: Despite advances in spinal biomechanic research, surgical techniques, and rehabilitation processes, no significant improvement has been identified in the treatment of spinal cord injury (SCI) and neurological ... -
Role of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats
Dincel, Gungor Cagdas; Yildirim, Serkan; Kul, Oguz (Ankara Univ Press, 2018)Type 1 diabetes mellitus (T1DM) is a severe chronic metabolic disorder characterized by hyperglycaemia because of the alterations in insulin secretion or its action. It is previously shown that hyperglycemia related oxidative ... -
Role of oxidative stress in the pathophysiology of Toxoplasma gondii infection
Dincel, Gungor Cagdas; Atmaca, Hasan Tarik (Sage Publications Inc, 2016)Oxidative stress (OS) plays an essential role in the pathogenesis of common neurodegenerative diseases. We have previously shown that Toxoplasma gondii (T. gondii) induces high nitric oxide (NO) production, glial activation, ...