Yazar "Oguztuzun, Serpil" için listeleme
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Apoptotic and necrotic effects of carboxylated quercetin/polyethylenimine complex on HeLa cells
Ulug, Murat; Turk, Mustafa; Oguztuzun, Serpil; Menemen, Yusuf; Kahraman, Gulten (Academic Journals, 2011)The effects of quercetin (Q), carboxylated quercetin (CQ) and carboxylated quercetin/polyethylenimine (CQ/PEI) complex on HeLa cell cultures were investigated. Firstly, carboxylated quercetin was acquired through hydroxyl ... -
Apoptotic and necrotic effects of plant extracts belonging to the genus Alchemilla L. species on HeLa cells in vitro
Turk, Mustafa; Kaya, Bulent; Menemen, Yusuf; Oguztuzun, Serpil (Academic Journals, 2011)Apoptotic and necrotic effects of plant extracts belonging to the genus Alchemilla on HeLa cells were investigated. The ratio of viable cells was determined by cell counter. Double staining method for the determination of ... -
Biochemical and histopathologic assessment of effects of acitretin on epiphyseal growth plate in rats
Onder, Sevda; Bilgili, Serap Gunes; Bulut, Gulay; Celik, Huseyin Tugrul; Oguztuzun, Serpil; Onder, Haci; Calka, Omer (TERMEDIA PUBLISHING HOUSE LTD, 2020)Introduction: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature. Aim: To ... -
Comparison of the tissue expressions of glutathione S transferase isoenzymes among patients with morphea and healthy controls: A preliminary study
Uzuncakmak, Tugba Kevser; Koska, Mahmut Can; Ozkanli, Seyma; Kocdogan, Arzu Kaya; Oguztuzun, Serpil; Karadag, Ayse Serap; Akdeniz, Necmettin (WILEY, 2020)Morphea is an inflammatory connective tissue disorder, which is characterized by sclerosis in skin and subcutaneous tissues with a chronic progress. The oxidative stress in pathogenesis of sclerosing diseases was proposed ... -
Comparison of TLR-2, TLR-4, and antimicrobial peptide levels in different lesions of acne vulgaris
Ozlu, Emin; Karadag, Ayse Serap; Ozkanli, Seyma; Oguztuzun, Serpil; Kilic, Murat; Zemheri, Ebru; Akdeniz, Necmettin (Taylor & Francis Ltd, 2016)Context: Recent studies have shown that tolls like receptors (TLRs) and antimicrobial peptides (hBD-1, cathelicidin) play an important role in the pathogenesis of acne vulgaris (AV).Objective: To evaluate and report the ... -
Cytotoxicity and apoptotic effects of nickel oxide nanoparticles in cultured HeLa cells
Ada, Kezban; Turk, Mustafa; Oguztuzun, Serpil; Kilic, Murat; Demirel, Mehmet; Tandogan, Nisa; Latif, Ozturk (Via Medica, 2010)The aim of this study was to observe the cytotoxicity and apoptotic effects of nickel oxide nanoparticles on human cervix epithelioid carcinoma cell line (HeLa). Nickel oxide precursors were synthesized by an nickel ... -
The Effect of CYP1A1 and GSTP1 Isozymes on the Occurrence of Aortic Aneurysms
Simsek, Erdal; Kilic, Murat; Simsek, Gulcin; Oguztuzun, Serpil; Moran, Busra; Saritas, Ahmet; Ulus, A. Tulga (Georg Thieme Verlag Kg, 2015)Background Aortic aneurysms are vascular diseases that are associated with high mortality and morbidity. Cytochrome P450 CYP1A1 and glutathione S-transferase (GSTP1) isozymes were searched and compared with the patients ... -
Effects of Different Doses of Systemic Isotretinoin on Eyes: A Histopathological and Immunohistochemical Study in Rats
Karadag, Remzi; Karadag, Ayse Serap; Ozlu, Emin; Oguztuzun, Serpil; Simsek, Gulcin Guler; Esmer, Oktay; Bilgili, Serap Gunes (Lippincott Williams & Wilkins, 2020)Purpose: To evaluate ocular side effects associated with systemic isotretinoin histopathologically. Methods: In this multicenter study, a total of 15 male and 15 female rats were randomly divided into 3 equal groups according ... -
Evaluation of oxidative stress via protein expression of glutathione S-transferase and cytochrome p450 (CYP450) soenzymes in psoriasis vulgaris patients treated with methotrexate
Akbulak, Ozge; Karadag, Ayse Serap; Akdeniz, Necmettin; Ozkanli, Seyma; Ozlu, Emin; Zemheri, Ebru; Oguztuzun, Serpil (Taylor & Francis Ltd, 2018)Introduction: Oxidative stress is the imbalance between oxidant-antioxidant systems and may play a major role in the psoriasis pathogenesis. Cytochrome (CYP) is a family of enzymes that are responsible for the metabolism ... -
Expression of antimicrobial peptides in recurrent adenotonsillitis
Demir, Mehmet Gokhan; Aydin, Sedat; Erdogan, Banu Atalay; Oguztuzun, Serpil; Kilic, Murat; Barisik, Nagehan Ozdemir (Walter De Gruyter Gmbh, 2016)Background: Recurrent acute tonsillitis is one of the most frequent otorhinolaryngology clinic referrals, yet its pathogenesis remains poorly understood. Antimicrobial cationic peptides are components of the innate system. ... -
Expression of glutathione-S-transferases isoenzymes and p53 in exfoliated human bladder cancer cells
Oguztuzun, Serpil; Sezgin, Yasemin; Yazici, Sertac; Firat, Pinar; Ozhavzali, Muzeyyen; Ozen, Haluk (Elsevier Science Inc, 2011)Objectives: This study investigates the usefulness of glutathione-S-transferases (GST) isoenzymes and p53 immunostaining as a marker of malignancy in urinary cytology, and evaluates their potential effect in increasing ... -
The expression of GST and CYP isoenzymes in thyroid nodular hyperplasia and papillary thyroid cancer tissue: Correlation with clinical parameters
Oguztuzun, Serpil; Ergn, Duygu; Kilic, Murat; Bozer, Busra; Simsek, Gulcin Guler; Bulus, Hakan (Entomology & Applied Science Research Letters-Easletters, 2016)This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase (GST) pi(P), mu(M), theta(T), omega(O) and kappa(K) cytochrome P450 (CYP) A1, B1 and 2E1 isoenzymes in thyroid nodular ... -
The expression of GST isoenzymes and p53 in non-small cell lung cancer
Oguztuzun, Serpil; Aydin, Mehtap; Demirag, Funda; Yazici, Ulku; Ozhavzali, Muzeyyen; Kilic, Murat; Iscan, Mesude (Via Medica, 2010)This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships ... -
The expression of GST isoenzymes in acinar adenocarcinoma, intraepithelial neoplasia, and benign prostate tissue: correlation of clinical parameters with GST isoenzymes
Simsek, Gulcin; Oguztuzun, Serpil; Guresci, Servet; Kilic, Murat; Bozkurt, Omer Faruk; Unsal, Ali (Tubitak Scientific & Technical Research Council Turkey, 2012)This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase (GST) alpha, pi, mu, and theta in prostatic acinar adenocarcinoma (PCA), prostatic intraepithelial neoplasia (PIN), and ... -
Expressions of CYP and GST Isoenzymes in Human Gastric Tumor and Non-Tumor Tissues
Simsek, Gulcin G.; Oguztuzun, Serpil; Bozer, Busra; Kilic, Murat; Kocdogan, Arzu K.; Kaygin, Pinar; Bulus, Hakan (Akad Doktorlar Yayinevi, 2018)In this study we investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1 and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 isoenzymes in gastric tumor and ... -
Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea
Takci, Zennure; Bilgili, Serap Gunes; Kilic, Murat; Oguztuzun, Serpil; Bozer, Busra; Simsek, Gulcin Guler; Akbayrak, Atiye (WILEY, 2020)Background Data point to the importance of oxidative stress in rosacea. Glutathione S-transferases (GSTs) have substantial roles in a wide variety of oxidative stress-related conditions. Aim To evaluate the immunohistochemical ... -
Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy
Aydin, Sedat; Demir, Mehmet Gokhan; Oguztuzun, Serpil; Kilic, Murat; Yilmaz, Can; Dirican, Onur (Palacky Univ, Medical Fac, 2019)Objectives. The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component. Although there are studies on ... -
Glutathione S-Transferases and Cytochrome P450 Enzyme Expression in Patients with Intracranial Tumors: Preliminary Report of 55 Patients
Kural, Cahit; Kocdogan, Arzu Kaya; Simsek, Gulcin Guler; Oguztuzun, Serpil; Kaygin, Pinar; Yilmaz, Irmak; Izci, Yusuf (Karger, 2019)Objective: Intracranial tumors are one of the most frightening and difficult-to-treat tumor types. In addition to surgery, protocols such as chemotherapy and radiotherapy also take place in the treatment. Glutathione ...
