Yazar "Okten, Salih" için listeleme
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Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions
Ekiz, Makbule; Tutar, Ahmet; Okten, Salih (Pergamon-Elsevier Science Ltd, 2016)The bromination of 2-aminobenzonitrile (2) with molecular bromine (2 equiv) furnished 2-amino-3,5-dibromobenzonitrile (7) in 98% yield. One-pot syntheses are described for dibromotacrine derivatives (6,14-18) utilizing ... -
Decision making for promising quinoline-based anticancer agents through combined methodology
Ozcan, Evrencan; Okten, Salih; Eren, Tamer (WILEY, 2020)During the development of effective drugs for the treatment of cancer, one of the most important tasks is to identify effective drug candidates having maximum antiproliferation and minimum side effects. This paper considers ... -
Detection of mechanism and anticancer activity of the new quinoline compounds MC20 and MC21
Koprulu, Tugba Kul; Tekin, Saban; Okten, Salih; Cinar, Merve; Duman, Seda; Cakmak, Osman (Elsevier Science Bv, 2014)… -
Determination of anticancer activities of some quinoline derivatives against C6 tumor cells
Sahin, Onem Yuce; Okten, Salih; Tekin, Saban; Cakmak, Osman (Elsevier Science Bv, 2012)… -
In vitro antiproliferative/cytotoxic activity of 2,3 '-biindole against various cancer cell lines
Okten, Salih; Erenler, Ramazan; Koprulu, Tugba Kul; Tekin, Saban (Tubitak Scientific & Technical Research Council Turkey, 2015)2,3'-Biindole (2) was synthesized via bromination of indole (1) with molecular bromine and underwent simultaneous dimerization. Antiproliferative and cytotoxic activity of 2 was investigated in vitro on C6 (rat brain tumor), ... -
Novel piperazine and morpholine substituted quinolines: Selective synthesis through activation of 3,6,8-tribromoquinoline, characterization and their some metabolic enzymes inhibition potentials
Cakmak, Osman; Okten, Salih; Alimli, Dilek; Ersanli, Cem Cuneyt; Taslimi, Parham; Kocyigit, Umit Muhammet (ELSEVIER, 2020)Regioselective routes are described for convenient preparation of novel piperazine/morpholine substituted quinoline derivatives at C-3, C-6 and C-8 starting with 3,6,8-tribromoquinoline (6) by nucleophilic substitution via ... -
Reinvestigation of bromination of 8-substituted quinolines and synthesis of novel phthalonitriles
Okten, Salih; Cakmak, Osman; Saddiqa, Aisha; Keskin, Bahadir; Ozdemir, Seda; Inal, Merve (Acg Publications, 2016)Bromination of a series of 8-substituted quinolines was reinvestigated and specified for optimum yields and isolation conditions. Mono bromination of 8-hydroxyquinoline (2a) and 8-aminoquinoline (2c) gave mixture of mono ... -
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors
Okten, Salih; Ekiz, Makbule; Tutar, Ahmet; Butun, Burcu; Kocyigit, Umit Muhammet; Topcu, Gulacti; Gulcin, Ilhami (Assoc Pharmaceutical Teachers India, 2019)Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ... -
A SAR Study: Evaluation of Bromo Derivatives of 8-Substituted Quinolines as Novel Anticancer Agents
Okten, Salih; Cakmak, Osman; Tekin, Saban; Koprulu, Tugba Kul (Bentham Science Publ Ltd, 2017)Background: Brominated 8-hydroxy, 8-methoxy, 8-amino quinolines 5, 6, 8, 9 and novel cyano 8-hydroxyquinolines 11, 12 were evaluated in vitro for their anticancer effects on various cell lines. 5,7-Dibromo-5, 7-bromo-6, ... -
Simple and convenient preparation of novel 6,8-disubstituted quinoline derivatives and their promising anticancer activities
Okten, Salih; Cakmak, Osman; Erenler, Ramazan; Yuce, Onem; Tekin, Saban (Scientific Technical Research Council Turkey-Tubitak, 2013)A short and easy route is described for 6,8-disubstituted derivatives of quinoline and 1,2,3,4-tetrahydroquinoline from 6,8-dibromoquinolines 2 and 7 by various substitution reactions. While copper-promoted substitution ... -
Synthesis Of Brominated Quinolines
Okten, Salih; Eyigun, Dilek; Cakmak, Osman (Yildiz Technical Univ, 2015)this study, bromination reactions of 1,2,3,4-tetrahydroquinoline by molecular bromine and aromatization reactions of brominated tetrahydroquinolines were reinvestigated. Optimal reaction conditions were established for ... -
Synthesis of novel cyano quinoline derivatives
Okten, Salih; Cakmak, Osman (Pergamon-Elsevier Science Ltd, 2015)6,8-Dibromo-1,2,3,4-tetrahydroquinoline (2) and 3,6,8-tribromoquinoline (3) were converted into the corresponding cyano derivatives via copper assisted nucleophilic substitution reactions. While bromination of 6-bromo-8- ... -
Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors
Ekiz, Makbule; Tutar, Ahmet; Okten, Salih; Butun, Burcu; Kocyigit, Umit M.; Taslimi, Parham; Topcu, Guelacti (Wiley-V C H Verlag Gmbh, 2018)We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ... -
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
Okten, Salih; Ekiz, Makbule; Kocyigit, Umit Muhammet; Tutar, Ahmet; Celik, Ismail; Akkurt, Mehmet; Gulcin, Ilhami (Elsevier Science Bv, 2019)The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...
