Yazar "Tutar, Ahmet" için listeleme
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Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions
Ekiz, Makbule; Tutar, Ahmet; Okten, Salih (Pergamon-Elsevier Science Ltd, 2016)The bromination of 2-aminobenzonitrile (2) with molecular bromine (2 equiv) furnished 2-amino-3,5-dibromobenzonitrile (7) in 98% yield. One-pot syntheses are described for dibromotacrine derivatives (6,14-18) utilizing ... -
Determination of anticancer and antibacterial activities of disubstituted tacrine derivatives
Ökten, Salih; Aydın, Ali; Tutar, Ahmet (2019)The present study describes the biological features of disubstituted tacrine derivatives using cell proliferation andcell cytotoxicity assays. The abilities of tacrine derivatives to inhibit microbial growth and to interact ... -
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors
Okten, Salih; Ekiz, Makbule; Tutar, Ahmet; Butun, Burcu; Kocyigit, Umit Muhammet; Topcu, Gulacti; Gulcin, Ilhami (Assoc Pharmaceutical Teachers India, 2019)Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ... -
Synthesis, characterization, and SAR of arylated indenoquinoline-based cholinesterase and carbonic anhydrase inhibitors
Ekiz, Makbule; Tutar, Ahmet; Okten, Salih; Butun, Burcu; Kocyigit, Umit M.; Taslimi, Parham; Topcu, Guelacti (Wiley-V C H Verlag Gmbh, 2018)We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ... -
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
Okten, Salih; Ekiz, Makbule; Kocyigit, Umit Muhammet; Tutar, Ahmet; Celik, Ismail; Akkurt, Mehmet; Gulcin, Ilhami (Elsevier Science Bv, 2019)The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ... -
Türk vergi hukukunda sahte veya muhteviyatı itibariyle yanıltıcı belge düzenleme ve kullanma
Tutar, Ahmet (Kırıkkale Üniversitesi, 2022)Sahte veya muhteviyatı itibariyle yanıltıcı belge düzenleme ve kullanma fiilleri, Türk vergi hukukunun en temel sorunlarından biri haline gelmiştir. Bu fiillerden kaynaklanan suçlar ülkemizde yaygın olarak işlenmektedir. ...
