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Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients
Oz, Merve Demirbugen; Baskak, Bora; Uckun, Zuhal; Artun, Nazan Yuce; Ozdemir, Hatice; Ozel, Tugba Kizil; Ozguven, Halise Devrimci (NATURE PUBLISHING GROUP, 2020)Sexual dysfunction (SD) is a troublesome adverse effect of selective serotonin reuptake inhibitors (SSRIs). A variety of mechanisms might be involved in the occurrence of SD but the exact mechanism is still not clear. ... -
Genotype and Allele Frequency of CYP3A4 -392A>G in Turkish Patients with Major Depressive Disorder
Uckun, Zuhal; Baskak, Bora; Özdemir, Hatice; Kızıl, Erguvan Tuğba Özel; Özgüven, Halise Devrimci; Süzen, Halit Sinan (2018)Objectives: Genetic polymorphisms may help for individualized drug dosing and improved therapeutics. CYP3A4 is responsible for the metabolism of more than 50% of the commonly used drugs and metabolizes typical antipsychotic ... -
Genotype and Allele Frequency of CYP3A4-392A > G in Turkish Patients with Major Depressive Disorder
Uckun, Zuhal; Baskak, Bora; Ozdemir, Hatice; Ozel-Kizil, Erguvan Tugba; Devrimci-Ozguven, Halise; Suzen, Halit Sinan (Turkish Pharmacists Assoc, 2018)Objectives: Genetic polymorphisms may help for individualized drug dosing and improved therapeutics. CYP3A4 is responsible for the metabolism of more than 50% of the commonly used drugs and metabolizes typical antipsychotic ... -
Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients
Yuce-Artun, Nazan; Baskak, Bora; Ozel-Kizil, Erguvan Tugba; Ozdemir, Hatice; Uckun, Zuhal; Devrimci-Ozguven, Halise; Suzen, Halit Sinan (Springer, 2016)Background Genetic polymorphisms in CYP2B6 and CYP2C19 may cause variability in the metabolism of sertraline, a widely used antidepressant in major depressive disorder treatment. Objective This study investigates the impact ... -
The relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients
Oz, Merve Demirbugen; Uckun, Zuhal; Yuce-Artun, Nazan; Baskak, Bora; Ozdemir, Hatice; Ozel, Tugba Kizil; Suzen, H. Sinan (Wiley, 2018)Objective: The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline ...
