dc.contributor.author | Nasseri, Behzad | |
dc.contributor.author | Turk, Mustafa | |
dc.contributor.author | Kosemehmetoglu, Kemal | |
dc.contributor.author | Kaya, Murat | |
dc.contributor.author | Piskin, Erhan | |
dc.contributor.author | Rabiee, Navid | |
dc.contributor.author | Webster, Thomas J. | |
dc.date.accessioned | 2021-01-14T18:11:06Z | |
dc.date.available | 2021-01-14T18:11:06Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Nasseri, B., Türk, M., Kosemehmetoglu, K., Kaya, M., Piskin, E., Rabiee, N., Webster, TJ. The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy. Int J Nanomedicine,15:2903-2920. | en_US |
dc.identifier.issn | 1178-2013 | |
dc.identifier.uri | https://doi.org/10.2147/IJN.S248327 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/12879 | |
dc.description | Rabiee, Navid/0000-0002-6945-8541; Kosemehmetoglu, Kemal/0000-0002-7747-0460; Kaya, Murat/0000-0002-2458-8924 | en_US |
dc.description | WOS:000527880400001 | en_US |
dc.description | PubMed: 32425523 | en_US |
dc.description.abstract | Background: The development of highly efficient nanoparticles to convert light to heat for anti-cancer applications is quite a challenging field of research. Methods: In this study, we synthesized unique pimpled gold nanospheres (PGNSs) for plasmonic photothermal therapy (PPTT). The light-to-heat conversion capability of PGNSs and PPTT damage at the cellular level were investigated using a tissue phantom model. The ability of PGNSs to induce robust cellular damage was studied during cytotoxicity tests on colorectal adenocarcinoma (DLD-1) and fibroblast cell lines. Further, a numerical model of plasmonic (COMSOL Multiphysics) properties was used with the PPTT experimental assays. Results: A low cytotoxic effect of thiolated polyethylene glycol (SH-PEG400-SH-) was observed which improved the biocompatibility of PGNSs to maintain 89.4% cell viability during cytometry assays (in terms of fibroblast cells for 24 hrs at a concentration of 300 mu g/mL). The heat generated from the nanoparticle-mediated phantom models resulted in Delta T=30 degrees C, Delta T=23.1 degrees C and Delta T=21 degrees C for the PGNSs, AuNRs, and AuNPs, respectively (at a 300 mu g/mL concentration and for 325 sec). For the in vitro assays of PPTT on cancer cells, the PGNS group induced a 68.78% lethality (apoptosis) on DLD-1 cells. Fluorescence microscopy results showed the destruction of cell membranes and nuclei for the PPTT group. Experiments further revealed a penetration depth of sufficient PPTT damage in a physical tumor model after hematoxylin and eosin (H&E) staining through pathological studies (at depths of 2, 3 and 4 cm). Severe structural damages were observed in the tissue model through an 808-nm laser exposed to the PGNSs. Conclusion: Collectively, such results show much promise for the use of the present PGNSs and photothermal therapy for numerous anti-cancer applications. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) | en_US |
dc.description.sponsorship | This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the 1003 classification project. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD | en_US |
dc.relation.isversionof | 10.2147/IJN.S248327 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | plasmonic | en_US |
dc.subject | photothermal therapy | en_US |
dc.subject | gold nanoparticles | en_US |
dc.subject | colorectal cells | en_US |
dc.subject | pathology | en_US |
dc.title | The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy | en_US |
dc.type | article | en_US |
dc.contributor.department | KKÜ | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.startpage | 2903 | en_US |
dc.identifier.endpage | 2920 | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |