dc.contributor.author | Saygun, Onur | |
dc.contributor.author | Eyigün, Can Polat | |
dc.contributor.author | Avcı, İsmail Yaşar | |
dc.contributor.author | Kısa, Üçler | |
dc.contributor.author | Pahsa, Alaaddin | |
dc.date.accessioned | 2021-01-14T18:16:22Z | |
dc.date.available | 2021-01-14T18:16:22Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Saygun O., Eyigün C. P., Avcı İ. Y., Kısa Ü., Pahsa A. (2009). Investigation (in vivo and in vitro) of booster dose vaccine requirement for long-term protection against hepatitis b virus infection. Turkish Journal of Medical Sciences, 39(2), 173 - 177. | en_US |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://app.trdizin.gov.tr/makale/T1RBek56QXc | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/13144 | |
dc.description.abstract | Aim: Studies have shown that no booster dose was required at least 10 to 15 years after a primary vaccination for individuals who developed protective anti-hepatitis B surface (anti-HBs) antibodies. In this study, booster dose requirement for HBV after primary immunization was investigated. Materials and Methods: Seventeen individuals vaccinated previously were enrolled in the study. They had once developed a protective level of anti-HBs antibody after immunization and their anti-HBs titer had declined to an underprotective level. Twenty uninfected and unvaccinated healthy people were chosen as controls. Lymphoproliferative response to in-vitro stimulation with hepatitis B surface antigen (HBsAg) and anti-HBs response to vaccine were evaluated for immune response. Results: T lymphocytes from 4 (24%) of the study group showed lymphoproliferative response to HBsAg stimulation while none of the controls did (P < 0.05). In all subjects in the study group, anti-HBs response (?10 mIU/ml) was detected 1 to 7 days after the booster injection but in only 2 of the controls antibody response was detected 28 days after the first dose of HBV vaccine (P < 0.0001). Conclusions: A booster dose of HBV vaccine might not be required because of immunological memory. | en_US |
dc.description.abstract | Aim: Studies have shown that no booster dose was required at least 10 to 15 years after a primary vaccination for individuals who developed protective anti-hepatitis B surface (anti-HBs) antibodies. In this study, booster dose requirement for HBV after primary immunization was investigated. Materials and Methods: Seventeen individuals vaccinated previously were enrolled in the study. They had once developed a protective level of anti-HBs antibody after immunization and their anti-HBs titer had declined to an underprotective level. Twenty uninfected and unvaccinated healthy people were chosen as controls. Lymphoproliferative response to in-vitro stimulation with hepatitis B surface antigen (HBsAg) and anti-HBs response to vaccine were evaluated for immune response. Results: T lymphocytes from 4 (24%) of the study group showed lymphoproliferative response to HBsAg stimulation while none of the controls did (P < 0.05). In all subjects in the study group, anti-HBs response (&#8805;10 mIU/ml) was detected 1 to 7 days after the booster injection but in only 2 of the controls antibody response was detected 28 days after the first dose of HBV vaccine (P < 0.0001). Conclusions: A booster dose of HBV vaccine might not be required because of immunological memory. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cerrahi | en_US |
dc.title | Investigation (in vivo and in vitro) of booster dose vaccine requirement for long-term protection against hepatitis b virus infection | en_US |
dc.title.alternative | Hepatit B virüsüne karşı aşılamada uzun süreli korunma için booster doz gerekliliğinin (in vivo ve in vitro) araştırılması | en_US |
dc.type | article | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 173 | en_US |
dc.identifier.endpage | 177 | en_US |
dc.relation.journal | Turkish Journal of Medical Sciences | en_US |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | en_US |