• Endokannabinoidlerin uterus düz kas yanıtları üzerine peroksizom-proliferatörlerince aktive olan reseptörler aracılı etkisi 

  Ünlü, Gülhan (Kırıkkale Üniversitesi, 2014)

  Endokannabinoidler pek çok dokuda fonksiyonların düzenlenmesine katkısı olduğu gösterilmiş endojen mediyatörlerdir. Endokannabinoidler etkilerini kannabinoid reseptörü tip 1 (CB1), kannabinoid reseptörü tip 2 (CB2), geçici ...

• The Role of Nitric Oxide Related Therapeutics in the Treatment of Cardiovascular Pathologies 

  Derici, Mehmet Kürşat; Yılmaz, Emine Demirel (2018)

  The heart is a bio pump responsible for the provision of oxygen and nutrients to all body cells. It plays a vital role in the survival of the organism. The essential function of the heart is performed through the close ...

• The Physiological And Dna Damage Response Of In The Lichen Hypogymnia Physodes To Uv And Heavy Metal Stress 

  Hamutoolu, R.; Derici, M. K.; Aras, E. S.; Aslan, A.; Cansaran-Duman, D. (CORVINUS UNIV BUDAPEST, 2020)

  This work aims to determine the response of Hypogymnia physodes (L.) Nyl. (hooded tube lichen) collected in an unpolluted site (Yenice Forest in Karabiik, Turkey) to stress conditions. In the present study, the effect of ...

• Role of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in rats 

  Dumludag, Burak; Derici, Mehmet Kursat; Sutcuoglu, Osman; Ogut, Betul; Pasaoglu, Ozge Tugce; Gonul, Ipek Isik; Derici, Ulver (TAYLOR & FRANCIS LTD, 2020)

  Silymarin (Silybum marianum) has some protective effects against drug toxicity (cisplatin, acetaminophen, adriamycin, gentamicin etc.). Colistin is a strong antimicrobial, which is frequently used in the treatment of ...

• Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients 

  Korucu, Berfu; Derici, Mehmet Kursat; Deger, Serpil Muge; Cokay, Abdurrahman; Helvaci, Ozant; Elbeg, Sehri; Derici, Ulver (AVES, 2020)

  Objective: Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipose tissue and macrophages. It regulates cholesterol trafficking and is involved in atherosclerosis formation. A-FABP levels are associated with ...

• Effects of medium cut-off dialysis membranes on inflammation and oxidative stress in patients on maintenance hemodialysis 

  Yeter, Hasan Haci; Korucu, Berfu; Akcay, Ömer Faruk; Derici, Kürşat; Derici, Ülver; Arinsoy, Turgay (SPRINGER, 2020)

  Purpose Medium cut-off membranes were developed for providing increased clearance of larger middle-molecule uremic toxins. We compared the effect of low-flux, medium cut-off, and high-flux membranes on chronic inflammation ...

• Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation 

  Müderrisoğlu, Ahmet; Babaoğlu, Elif; Korkmaz, Elif Tuğçe; Ongun, Mert C.; Karabulut, Erdem; İskit, Alper B.; Emri, Salih (FRONTIERS MEDIA SA, 2020)

  Objectives To determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population. Methods 130 smokers and 130 ...

• Differential expressions and functions of phosphodiesterase enzymes in different regions of the rat heart 

  Derici, Mehmet Kursat; Sadi, Gokhan; Cenik, Basar; Guray, Tulin; Demirel-Yilmaz, Emine (Elsevier Science Bv, 2019)

  Phosphodiesterase enzymes (PDEs) are responsible for the adjustment of cyclic nucleotide levels. Alterations in PDE expressions in different tissues cause conflicts between functional and clinical effects of PDE inhibitors. ...

• A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate 

  Yildirim, Engin; Derici, Mehmet Kursat (Int Scientific Information, Inc, 2019)

  Background: Polycystic ovary syndrome (PCOS) is associated with infertility or subfertility due to impaired ovulation. Clomiphene citrate is a first-line treatment option for the induction of ovulation in women with PCOS. ...

• Is it possible to prevent contrast-induced nephropathy with dexpanthenol? 

  Sutcuoglu, Osman; Derici, Mehmet Kursat; Pasaoglu, Ozge Tugce; Dumludag, Burak; Helvaci, Ozant; Ogut, Betul; Derici, Ulver (Springer, 2019)

  PurposeContrast-induced nephropathy (CIN) is one of the side effects of diagnostic procedures. Oxidative stress plays an important role in CIN's pathophysiology. Dexpanthenol (Dexp) is a substance with antioxidant efficacy. ...

• Skin-homing T-cell responses associated with Demodex infestation and rosacea 

  Gazi, Umut; Gureser, Ayse Semra; Oztekin, Aynure; Karasartova, Djursun; Kosar-Acar, Nezahat; Derici, Mehmet Kursat; Taylan-Ozkan, Aysegul (Wiley, 2019)

  Aims Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; ...

• Is the Concentration of Cadmium, Lead, Mercury, and Selenium Related to Preterm Birth? 

  Yildirim, Engin; Derici, Mehmet Kuersat; Demir, Emre; Apaydin, Hakan; Kocak, Ozguer; Kan, Ozguer; Gorkem, Umit (Humana Press Inc, 2019)

  Environmental pollution and exposure of people to heavy metals cause many bad obstetric outcomes. Our aim is to demonstrate the role of cadmium (Cd), lead (Pb), mercury (Hg), and selenium (Se) in preterm labor etiology ...

• Dexmedetomidine as an Alternative Anesthetic Agent for Flap Surgery: An Intravital Evaluation in the Cremaster Muscle Flap 

  Gencay, Isin; Boybeyi, Ozlem; Unlu, Gulhan; Yazici, Ilker; Aydin, Gulcin; Buyukkocak, Unase (Lippincott Williams & Wilkins, 2019)

  Introduction: Flap surgery is one of the most commonly used techniques of reconstructive surgery for effective repair of damaged tissue. Optimal anesthetic technique and anesthetic agent plays an important role in flap ...

• Autophagy: A New Therapeutic Target 

  Ceylan, Asli F. (Academic Press Ltd-Elsevier Science Ltd, 2018)

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• What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? 

  Sayan, Cemile Dayangan; Karaca, Gokhan; Ozkan, Zehra Sema; Tulmac, Ozlem B.; Isik, Asli Ceylan; Devrim, Tuba; Yeral, Ilkin (Wiley, 2018)

  AimThe aim of this study was to investigate the protective effect of metformin on the rat ovary against ischemia-reperfusion injury. MethodsThirty-seven female Wistar albino rats were used in the study. The rats were divided ...

• Usnic acid causes apoptotic-like death in Leishmania major, L. infantum and L. tropica 

  Derici, Mehmet Kursat; Cansaran-Duman, Demet; Taylan-Ozkan, Aysegul (Springer Heidelberg, 2018)

  Leishmaniasis, a deadly parasitic infection, threatens many people worldwide. Since the high cost, toxicity, and resistance are drawbacks of current treatment options, it is necessary to find safer and more effective new ...

• Evaluation of in vitro Anticancer Activity of Vulpinic Acid and its Apoptotic Potential Using Gene Expression and Protein Analysis 

  Kilic, Nil; Derici, Mehmet Kursat; Buyuk, Ilker; Aydin, Semra Soydam; Aras, Sumer; Cansaran-Duman, Demet (Assoc Pharmaceutical Teachers India, 2018)

  Lichens and their secondary metabolite are still among the many unexamined natural sources in the drug industry. This study was designed to evaluate the cytotoxic effects of vulpinic acid lichen secondary metabolite and ...

• Synthesis, structural characterization and myorelaxant activity of 4-naphthylhexahydroquinoline derivatives containing different ester groups 

  Gunduz, Miyase Gozde; Albayrak, Emine; Isli, Fatma; Fincan, Gokce Sevim Ozturk; Yildirim, Seniz; Simsek, Rahime; Butcher, Ray J. (Serbian Chemical Soc, 2016)

  The present study reports the synthesis, structural characterization and myorelaxant activity evaluation of a series of 16 novel 4-naphthylhexahydroquinoline derivatives. The compounds were achieved by one-pot microwave-assisted ...

• Effects of chronic L-DOPA administration on neurogenic and endothelium-dependent relaxation responses in rabbit corpus cavernosum 

  Yildirim, Seniz; Fincan, Gokce Sevim Ozturk; Isli, Fatma; Ercan, Sevim; Sarioglu, Yusuf (Polish Acad Sciences Inst Pharmacology, 2016)

  Background: Dopamine is a crucial central neurotransmitter that plays a fundamental role in the autonomic and somatic components of penile reflexes in animals and humans. Similar to the erectile responses of dopamine, ...

• Role of nicotinic acetylcholine receptor subtypes on nicotine's enhancing effect on electrical field stimulation elicited contractile responses in rabbit urine bladder 

  Fincan, G. S. Ozturk; Vural, I. M.; Yildirim, S. S.; Isli, F.; Dilekoz, E.; Ercan, S.; Sarioglu, Y. (Verduci Publisher, 2016)

  OBJECTIVE: This study aims to investigate the contribution of presynaptic nicotinic acetylcholine receptors (nAChRs) sub-types to nicotine-induced enhancement in electrical field stimulation (EFS) EFS-mediated contractile ...

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