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dc.contributor.authorAkbal E.
dc.contributor.authorGüneş F.
dc.contributor.authorAşik M.
dc.contributor.authorÖzbek M.
dc.contributor.authorÜreten K.
dc.contributor.authorAltinbaş M.
dc.date.accessioned2020-06-25T15:17:24Z
dc.date.available2020-06-25T15:17:24Z
dc.date.issued2013
dc.identifier.issn13012193
dc.identifier.urihttps://doi.org/10.4274/Tjem.2309
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2347
dc.description.abstractPurpose: Hereditary haemochromatosis (HH) is a genetic disease with autosomal recessive trait. Recent studies demonstrated the importance of C282Y gene mutation in the aetiology of HH. Free iron accumulating in pancreas deteriorates insulin secretion and synthesis which can lead to insulin resistance and the development of type 2 diabetes mellitus (T2DM) in patients with HH. There has been no study determining the prevalence of haemochromatosis gene (HFE) mutations and HH in diabetic patients in Turkey. We planned this study in order to investigate the C282Y and H63D mutation that cause HH in T2DM. Material and Method: In this study, we included185 patients with T2DM. Patients older than thirty-five years, not taking vitamin supplementation, iron preparates and/or oral contraceptives and those without any signs of active bleeding were included while patients with any infectious, systemic or immune disease were excluded from the study. Serum transferrin saturation (TS), ferritin, iron, and total iron binding capacity levels were measured after 12 hours of fasting. Results: Ten (5.4%) cases with TS of more than 45% were detected at the first evaluation. The test was repeated in those cases and 6 patients with TS of more than 45% were left according to the second measurement. H63D and C282Y gene polymorphisms were not present in these patients. Discussion: We did not find any correlation between the existence of T2DM and HFE polymorphisms. We assume that screening for HH in T2DM in our population is not needed.en_US
dc.language.isoengen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.isversionof10.4274/Tjem.2309en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemochromatosisen_US
dc.subjectTransferrin saturationen_US
dc.subjectType 2 diabetesen_US
dc.titleHFE gene mutation among Turkish patients with type 2 diabetes mellitusen_US
dc.title.alternativeTürk tip 2 diabetik hastalar arasında HFE gen mutasyonuen_US
dc.typearticleen_US
dc.contributor.departmentKırıkkale Üniversitesien_US
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.startpage89en_US
dc.identifier.endpage91en_US
dc.relation.journalTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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