The effect of albendazole and praziquantel on Strobilocercus fasciolaris in experimentally infected mice

Abstract

This study was conducted to analyze the effects of albendazole and praziquantel on the development and treatment of S. fasciolaris. In order to determine the prophylactic effects on the development of S. fasciolaris, the drugs (albendazole and praziquantel) were given 2 days before the infection and for a period of 30 days. Also, to determine the effects of treatment, both drugs were given on the 63(rd) day of the infection and for a period of 14 days. The dosages of albendazole and praziquantel were 15 mg/kg (150 ppm) and 200 mg/kg (2000 ppm) respectively. They were given with the normal daily diet. In the group in which albendazole had a prophylactive effect on the development of S. fasciolaris, no macroscopic cystic development was observed. However, in the histological sections of the livers, some microscopic cystic structures were found. In the group in which the effects of the drug were tested ail the cysts were affected. In the group in which the prophylactic effects of praziquantel on cyst development were tested, it was observed that the drug had no effect on the development of cysts, but compared to the positive control group (no drugs given), the drug reduced the number of cysts in the liver. The effects of praziquantel on the developing S. fasciolaris were calculated to be 27.2%, The preventive effect of praziquantel on the developed S. fasciolaris was calculated to be 93.4%. As a result, while prophylactic effects of albendazole on the development of S. fasciolaris were observed, no such effects were observed with praziquantel. Both drugs were effective in the treatment of developing cysts.