dc.contributor.author | Muluk, NB | |
dc.contributor.author | Kisa, U | |
dc.contributor.author | Kacmaz, M | |
dc.contributor.author | Apan, A | |
dc.contributor.author | Koc, C | |
dc.date.accessioned | 2020-06-25T17:40:53Z | |
dc.date.available | 2020-06-25T17:40:53Z | |
dc.date.issued | 2005 | |
dc.identifier.issn | 0194-5998 | |
dc.identifier.issn | 1097-6817 | |
dc.identifier.uri | https://doi.org/10.1016/j.otohns.2004.09.012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/3577 | |
dc.description | KISA, Ucler/0000-0002-8131-6810 | en_US |
dc.description | WOS: 000226216300025 | en_US |
dc.description | PubMed: 15632925 | en_US |
dc.description.abstract | OBJECTIVE: The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on antioxidant enzymes (SOD, CAT, and GSH-Px) and TBA-RS values of the submandibular glands of the rabbits. STUDY DESIGN AND SETTING: The study was conveyed in two groups (Group I, II) and control with a total of 24 rabbits. Eight rabbits in group I received intravenous (i.v.) topotecan (0.25 mg/kg once daily) for 3 days. Eight rabbits in group II received i.v. topotecan (0.5 mg/kg once daily) for 3 days. On the 15th day after administration of topotecan, submandibular glands were removed and levels of the SOD, CAT, and GSH-Px and the TBA-RS in the submandibular glands of the rabbits were examined. RESULTS: SOD, CAT, and GSH-Px values were significantly higher in high-dose topotecan group compared to control group (P < 0.05). SOD and TBA-RS values were significantly higher in high-dose topotecan group compared to low-dose topotecan group (P < 0.05). CONCLUSION: It was concluded that, to prevent the hazardous effects of oxygen free radicals due to topotecan, antioxidant enzymes SOD, CAT, and GSH-Px were increased. The higher levels of the TBA-RS values in group II showed that permanent damage was present because of high-dose topotecan administration in the submandibular glands of the rabbits. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.relation.isversionof | 10.1016/j.otohns.2004.09.012 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | Efficacy of topotecan treatment on antioxidant enzymes and TBA-RS levels in submandibular glands of rabbits: An experimental study | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 132 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 136 | en_US |
dc.identifier.endpage | 140 | en_US |
dc.relation.journal | Otolaryngology-Head And Neck Surgery | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |