dc.contributor.author | Kavut, A. Baccioglu | |
dc.contributor.author | Kalpaklioglu, F. | |
dc.contributor.author | Birben, E. | |
dc.contributor.author | Ayaslioglu, E. | |
dc.date.accessioned | 2020-06-25T18:06:49Z | |
dc.date.available | 2020-06-25T18:06:49Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.issn | 1018-9068 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/5365 | |
dc.description | WOS: 000305365200007 | en_US |
dc.description | PubMed: 22697010 | en_US |
dc.description.abstract | Background: The development of allergic hypersensitivity depends on both genetic and environmental factors. Different amounts of microbial products could affect patients with atopy and different genotypes. Objective: We aimed to evaluate the role of varying degrees of exposure to infection by Mycobacterium tuberculosis (tuberculosis) in atopic patients and analyze the association with genetic factors. Methods: We performed CD14-159C/T genotyping in atopic patients (n=118) and healthy individuals (n=62) and recorded the following variables: rural lifestyle, exposure to persons with tuberculosis, bacille Calmette-Guerin (BCG) vaccination, tuberculin skin test (TST), skin prick test, and phenotypes of atopy. Blood samples were analyzed for soluble-CD14 (sCD14), interferon (IFN) gamma, total immunoglobulin (Ig) E, and eosinophil levels. A score was used to identify the likelihood of exposure to tuberculosis. Results: Almost all the study participants had had a BCG vaccination, and half had a positive TST result. No differences were observed between atopic patients with high/low tuberculosis scores and CD14 genotypes in terms of atopic phenotypes, allergen sensitization, and levels of total IgE, sCD14, and IFN-gamma. However, the frequency of asthma was higher in atopic patients with a high tuberculosis score and was not associated with CD14 genotypes. Eosinophil counts in blood were higher in atopic patients with a high tuberculosis score and CC+CT genotypes. Conclusions: These results suggest that the C allele of the CD14-159C/T polymorphism has a marked effect on eosinophil levels in atopic patients with increased exposure to tuberculosis. In addition, the degree of exposure to tuberculosis in atopic patients may modify the development of asthma. | en_US |
dc.description.sponsorship | Kirikkale UniversityKirikkale University [2008/5] | en_US |
dc.description.sponsorship | This work was supported by a grant from Kirikkale University Projects of Scientific Research (Grant No. 2008/5) awarded to Drs Baccioglu Kavut, Kalpaklioglu, and Ayaslioglu. None of the authors have any other financial disclosures to make. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Esmon Publicidad S A | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Atopy | en_US |
dc.subject | BCG | en_US |
dc.subject | CD14 polymorphism | en_US |
dc.subject | Rural life | en_US |
dc.subject | Tuberculosis | en_US |
dc.title | Association Between Tuberculosis and Atopy: Role of the CD14-159C/T Polymorphism | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 201 | en_US |
dc.identifier.endpage | 207 | en_US |
dc.relation.journal | Journal Of Investigational Allergology And Clinical Immunology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |