Association and expression analysis of porcine HNF1A gene related to meat and carcass quality traits
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Tarih
2013Yazar
Kayan, AutcharaUddin, Muhammad Jasim
Kocamis, Hakan
Tesfaye, Dawit
Looft, Christian
Tholen, Ernst
Cinar, Mehmet Ulas
Üst veri
Tüm öğe kaydını gösterKünye
closedAccessÖzet
The aim of this study was to investigate the association and expression of HNF1A gene as a candidate gene for meat and carcass quality traits in pigs. Statistical analysis revealed that the g.8260 A>G polymorphism significantly associated with pH 24(H), meat percentage and muscle area in the F-2 Duroc x Pietrain (DuPi, n = 313) and with pH 24(L), fat area and backfat thickness in the Pietrain (Pi, n = 110) population. HNF1A mRNA and protein expressions were higher (p < 0.05) in animals with the low post-mortem muscle pH 24(L). The promoter methylation profiling suggested that methylation was not involved on HNF1A expression regulation (p > 0.05) in animal with divergent muscle pH. In conclusion, polymorphism in porcine HNF1A gene could be used as a candidate marker to improve the meat and carcass quality traits, with the consideration of breed-specific effect. (C) 2013 Elsevier Ltd. All rights reserved.