Microwave-assisted synthesis of alginate-g-polyvinylpyrrolidone copolymer and its application in controlled drug release

Abstract

The aim of this study is to synthesize graft copolymer (NaAlg-g-PVP) in microwave oven and prepare pH-responsive beads with high entrapment efficiency. For this purpose, PVP was grafted onto sodium alginate using microwave radiation. The copolymer obtained was characterized using FTIR, H-1-NMR, elemental analysis and thermogravimetric analysis. A series of NaAlg-g-PVP beads were prepared as drug delivery matrices for ibuprofen (IB) by cross-linking into beads via glutaraldehyde. The chemical stability of IB after encapsulation into beads was confirmed by FTIR, DSC, and X-RD analysis. Synthesis conditions of beads were optimized by considering entrapment efficiency, particle size, swelling capacity and their release data. Effects of such variables as graft yield and drug/polymer ratio were investigated at 1.2 and 7.4 pH values. Increasing the drug/polymer ratio and extent of cross-linking caused decrease in the IB release. On the other hand, increase in the graft yield led to increase in the IB release as well. The results also showed that NaAlg-g-PVP beads were positive pH-responsive.