Research of MFG-E8, OPG and SOCS-3 on preeclampsia

Abstract

Preeclampsia is a specific disease and closely associated with systemic inflammatory response. The aim of this study is research to possible role of some inflammatory factors and the controlling factor in inflammation in the etiology of preeclampsia or reflection of this situation on placental tissue. Three parameters were included in the study regarded as potential risk factors: Milk Fat Globul Epidermal Growth Factor-8 (MFG-E8); is an endometrial epithelial proteins and regulates inflammation and apoptosis. MFG-E8 is an important in the development of endometrium and chorionic villus. Osteoprotegerin (OPG); is pro-angiogenic factor, it can be important for plasental angiogenesis. Suppressor of cytokine signaling-3 Receptor (SOCS-3) has a role on prevents the inflammation. Serum and placental tissue samples were used as materials. Control group is composed of 50 healthy women volunteers with no history of preeclampsia and 28–34th weeks of pregnancy. The experimental group consisted 40 preeclamptic women in 28–34th week of pregnancy. All of the measurement analyzed through the ELISA (Enzyme-Linked Immuno Sorbent Analysis) method and findings evaluated comparatively. MFG-E8, SOCS-3 and OPG levels analysed with ELISA in the serum and placental tissue. OPG levels in serum raised and displayed statistically significant difference with respect to control group (p<0.01). In respect to the serum MFG-E8 and SOCS-3 are not observed any difference between two groups. MFG-E8 tissue levels are statistically significantly low in preeclamptic group with respect to healthy control group and that there is no changes in the levels of SOCS-3 (p<0.01).