Is there a relation between mean platelet volume and chronic kidney disease stages in diabetic patients?

Abstract

Objective: Chronic kidney disesase (CKD) is a state of atherosclerotic and chronic inflammation and as the estimated glomerular filtration rate (GFR) declines, cardiovascular disease (CVD) risk and inflammation increase. Mean platelet volume (MPV) has shown to be influenced by cardiovascular risk factors. The aim of this study was to evaluate the relationship between MPV and CKD. Methods: This is prospective study of a total of 812 CKD patients. Patients with CKD were assigned to into the five groups depending on estimated GFR which were calculated by Modification of Diet in Renal Disease (MDRD). Patients demographics, comorbid disease were recorded, and laboratory variables were also evaluated. Results: The mean age of CKD patients was 62.6 +/- 15.4 years. According to stages, 96 patients (11.8%) were classified as stage 1 (GFR >90 ml/min/1.73 m(2)), 77 patients (9.5%) as stage 2 (GFR 89-60 ml/min/1.73 m(2)), 306 patients (37.7%) as stage 3 (GFR 59-30 ml/min/1.73 m(2)), 198 (24.4%) patients as stage 4 (GFR 29-15 ml/min/1.73 m(2)) and 135 (16.6%) patients as stage 5 (GFR < 15 ml/min/1.73 m(2), dialysis and non-dialysis). DM was found to be positive in 299 (152 female; 147 male) patients. The mean MPV was found to higher in diabetic patients compared to non-diabetic patients (9.5 +/- 1.3 fL vs 9.3 +/- 1.4 fL, p: 0.024). There was a positive correlation between CKD stage and MPV in diabetic male patients. Conclusion: The results of our study might suggest that diabetic male patients with CKD have higher MPV values support the idea that these groups have additional risks other than CKD and these patients should be followed closely in respect to its complications.