dc.contributor.author | Koprulu, Tugba Kul | |
dc.contributor.author | Okten, Salih | |
dc.contributor.author | Tekin, Saban | |
dc.contributor.author | Cakmak, Osman | |
dc.date.accessioned | 2020-06-25T18:34:17Z | |
dc.date.available | 2020-06-25T18:34:17Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1095-6670 | |
dc.identifier.issn | 1099-0461 | |
dc.identifier.uri | https://doi.org/10.1002/jbt.22260 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/7852 | |
dc.description | Okten, Salih/0000-0001-9656-1803; Kul Koprulu, Tugba/0000-0001-9451-5715 | en_US |
dc.description | WOS: 000460550900001 | en_US |
dc.description | PubMed: 30431695 | en_US |
dc.description.abstract | Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N-oxide, and methoxy) quinoline derivatives (3-13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6-Bromo-5-nitroquinoline (4), and 6,8-diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5-fluorouracil (5-FU), while the other compounds showed low antiproliferative activity. 6-Bromo-5-nitroquinoline (4) possesses lower cytotoxic activity than 5-FU in HT29 cell line. Due to its the apoptotic activity 6-Bromo-5-nitroquinoline (4) has the potential to cause cancer cell death. | en_US |
dc.description.sponsorship | Turkiye Bilimsel ve Teknolojik Arastirma KurumuTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T394]; Scientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) | en_US |
dc.description.sponsorship | Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 112T394; Scientific and Technological Research Council of Turkey | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.isversionof | 10.1002/jbt.22260 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | apoptosis | en_US |
dc.subject | cancer cells | en_US |
dc.subject | cytotoxic activity | en_US |
dc.subject | nitroquinoline | en_US |
dc.subject | phenylquinoline | en_US |
dc.subject | quinolines | en_US |
dc.title | Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 3 | en_US |
dc.relation.journal | Journal Of Biochemical And Molecular Toxicology | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |