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dc.contributor.authorAksoy, E.
dc.contributor.authorAzkur, A. K.
dc.date.accessioned2020-06-25T18:34:28Z
dc.date.available2020-06-25T18:34:28Z
dc.date.issued2019
dc.identifier.citationclosedAccessen_US
dc.identifier.issn0001-723X
dc.identifier.issn1336-2305
dc.identifier.urihttps://doi.org/10.4149/av_2019_306
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7923
dc.descriptionAKSOY, Emel/0000-0001-9536-4322en_US
dc.descriptionWOS: 000485187300006en_US
dc.descriptionPubMed: 31507194en_US
dc.description.abstractSchmallenberg virus (SBV), a neurotropic member of the genus Orthobunyavirus, infects ruminants and causes neurological lesions and fetal malformations including cerebellar hypoplasia, hydranencephaly, and porencephaly. The aim of this study is to establish intracerebral (i.c.) infection of SBV in newborn BALB/c mice and to investigate some of the transcription factors in brain. For this aim, brain samples of newborn BALB/c mice which were infected with SBV i.c. were analyzed by plaque titration and real-time RT-PCR for T-bet, Gata3, RoR gamma t, Foxp3 and Eomes mRNA levels. Study results showed that SBV can replicate in BALB/c mice brain and cause death of newborn mice with generation of infectious viral particles. Analyses of transcription factor mRNA levels indicated up-regulation of T-bet, Gata3, RoR.t, Foxp3 and down-regulation of Eomes. In this report, we introduce preliminary data of T cell transcription factors affected by SBV infection of BALB/c mice.en_US
dc.language.isoengen_US
dc.publisherAepress Sroen_US
dc.relation.isversionof10.4149/av_2019_306en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEomesen_US
dc.subjectFoxp3en_US
dc.subjectGata3en_US
dc.subjectRoR gamma ten_US
dc.subjectSchmallenberg virusen_US
dc.subjectT-beten_US
dc.titleSchmallenberg virus affects T-bet, Gata3, RoRr gamma t, Foxp3 and Eomes in mice brainen_US
dc.typearticleen_US
dc.contributor.departmentKırıkkale Üniversitesien_US
dc.identifier.volume63en_US
dc.identifier.issue3en_US
dc.identifier.startpage286en_US
dc.identifier.endpage+en_US
dc.relation.journalActa Virologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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