dc.contributor.author | Sivgin, V | |
dc.contributor.author | Yalcin, G. | |
dc.contributor.author | Kucuk, A. | |
dc.contributor.author | Sezen, S. C. | |
dc.contributor.author | Afandiyeva, N. | |
dc.contributor.author | Arslan, M. | |
dc.date.accessioned | 2020-06-25T18:35:06Z | |
dc.date.available | 2020-06-25T18:35:06Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0006-9248 | |
dc.identifier.issn | 1336-0345 | |
dc.identifier.uri | https://doi.org/10.4149/BLL_2020_015 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/8118 | |
dc.description | WOS: 000508930100003 | en_US |
dc.description | PubMed: 32115963 | en_US |
dc.description.abstract | AIM: The aim of this study is to demonstrate whether fullerenol C60 protects renal injury in sevoflurane-administered rats. METHOD: Rats (n: 24) were randomly divided into four groups: Control (Group C), Fullerenol C60 (Group F), Sevoflurane (Group S), Fullerenol C60-Sevoflurane (Group FS). Thirty minutes before the procedure, Fullerenol C60, 100 mg/kg, was administered intraperitoneally. Sevoflurane (2.3 %) was applied for 3 hours to rats in S and FS groups. Biochemical and histopathological parameters were analyzed in renal tissue samples. Kruskal-Wallis and Mann-Whitney U tests were used in statistical analyzes. RESULTS: Malondialdehyde (MDA) level and catalase (CAT) enzyme activity in Group S were significantly higher than that in all other groups. Paraoxanase (PON) enzyme activity in Group S was significantly lower than in Groups C and FS. The histopathological examination showed that vascular vacuolization and hypertrophy (VVH) and lymphocyte infiltration (LI) were significantly higher in the Group S compared to the Group C. CONCLUSION: Renal histopathology revealed that the administration of Fullerenol C60 prior to sevoflurane inhalation reduced oxidative stress and partially corrected the damage caused by anesthesia. We concluded that Fullerenol C60 has a renal protective effect in rats when administered before sevoflurane anesthesia. | en_US |
dc.description.sponsorship | Gazi University Scientific Research Committee [01/2019-42] | en_US |
dc.description.sponsorship | This study was supported by Gazi University Scientific Research Committee (Scientific Research Project No. 01/2019-42). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Comenius Univ | en_US |
dc.relation.isversionof | 10.4149/BLL_2020_015 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | fullerenol C60 | en_US |
dc.subject | sevoflurane | en_US |
dc.subject | renal injury | en_US |
dc.subject | MDA | en_US |
dc.subject | PON-1 | en_US |
dc.title | Effects of fullerenol nanoparticles on kidney tissue in sevoflurane-treated rats | en_US |
dc.type | article | en_US |
dc.contributor.department | Kırıkkale Üniversitesi | en_US |
dc.identifier.volume | 121 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 117 | en_US |
dc.identifier.endpage | 121 | en_US |
dc.relation.journal | Bratislava Medical Journal-Bratislavske Lekarske Listy | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |