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Toplam kayıt 81, listelenen: 21-30
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
(Elsevier Science Bv, 2019)
The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...
SAR Evaluation of Disubstituted Tacrine Analogues as Promising Cholinesterase and Carbonic Anhydrase Inhibitors
(Assoc Pharmaceutical Teachers India, 2019)
Background: The inhibition of both hydrolysis products of acetylcholine (ACh), Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE), is essential for successful treatment of Alzhemier patients. Objectives: This ...
Aminopyrazole-substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties
(Wiley-V C H Verlag Gmbh, 2019)
The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ...
Convenient synthesis of disubstituted tacrine derivatives via electrophilic and copper induced reactions
(Pergamon-Elsevier Science Ltd, 2016)
The bromination of 2-aminobenzonitrile (2) with molecular bromine (2 equiv) furnished 2-amino-3,5-dibromobenzonitrile (7) in 98% yield. One-pot syntheses are described for dibromotacrine derivatives (6,14-18) utilizing ...
Effect of heat treatment on the microstructures and mechanical properties of Al-5.5Zn-2.5Mg alloy
(Elsevier Science Sa, 2016)
The Al-5.5 Zn-2.5 Mg (wt%) ternary alloy was prepared using a vacuum melting furnace and a casting furnace. Microstructural and mechanical properties of the alloy were investigated as-cast and under heat-treated conditions. ...
An Examination of Cross Sectional Change in Student's Metaphorical Perceptions towards Heat, Temperature and Energy Concepts
(Necmettin Erbakan Univ, 2016)
In science teaching, metaphors are important tools for understanding meaningful learning and conceptual formation by the help of daily life language. This study aims to evaluate how the concepts of heat, temperature and ...
Augmented reality in science laboratories: The effects of augmented reality on university students' laboratory skills and attitudes toward science laboratories
(Pergamon-Elsevier Science Ltd, 2016)
This study investigated the effects of the use of augmented reality (AR) technologies in science laboratories on university students' laboratory skills and attitudes towards laboratories. A quasi-experimental pre-test/post-test ...
The adaptation of the pedagogical knowledge and skills survey into Turkish: Validity and reliability study
(Mehmet Tekerek, 2019)
This research aims to adapt the Pedagogical Knowledge and Skills in Teaching (PKST) survey developed by Wong, Chong, Choy and Lim (2012) to Turkish. The participants of the study are 830 4th year students of education ...
The investigation of the healing effect of active ingredients in traditional medicinal plants on lung cancer
(HUMANA PRESS INC, 2020)
The healing effect of herbal active compounds on lung cancer has been recently investigated. Lung cancer is one of the leading types of cancer. The causes and prevention of lung cancer diagnosis have an important role as ...
Novel piperazine and morpholine substituted quinolines: Selective synthesis through activation of 3,6,8-tribromoquinoline, characterization and their some metabolic enzymes inhibition potentials
(ELSEVIER, 2020)
Regioselective routes are described for convenient preparation of novel piperazine/morpholine substituted quinoline derivatives at C-3, C-6 and C-8 starting with 3,6,8-tribromoquinoline (6) by nucleophilic substitution via ...