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    Effects of trauma and pain on the acute anterior pituitary hormonal response
    (Elsevier, 2002) Gözil, R.; Evrenkaya, T.; Keskil, Z.; Çalgüner, E.; Keskil, S.
    The aim of this study was to compare the effects of trauma and pain on the pituitary gland so as to determine whether pain is a significant component in the general acute hormonal trauma response. Adenohypophysis of rabbits that have undergone either diffuse traumatic brain injury or pain were investigated using immunohistochemistry. The ACTH staining pattern of the pain-administered rabbits was not as strong as the head-trauma-administered group, whereas PRL staining pattern of the former group was not so weak as the later group. As a conclusion, since adrenocorticotrophic hormone and prolactin staining patterns were different in the trauma administered and pain induced groups; it may be postulated that pain alone may not be an important factor in the hormonal response to trauma. © 2002 Published by Elsevier Science Ltd.
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    Öğe
    The immunohistochemical approach to determine the origin and possible function of the juxtaoral organ in dogs
    (Saudi Med J, 2005) Bahçelioğlu, M.; Çalgüner, E.; Erdoğan, D.; Elmas, C.; Gozil, R.; Keşkil, S.; Kadıoğlu, D.
    Objective: In this study, we applied immunohistochemical techniques on the functionally little known organ of Chievitz (juxtaoral organ [JOO]) in dogs to determine its origin and possible function. Methods: The term abortive materials of 6 Doberman dogs were used for experimental procedures in July 2002 to June 2003 at Gazi University Faculty of Medicine, Ankara, Turkey, after routine light microscopic tissue preparation, the sections were stained with Masson's trichrome stain. In order to elucidate the function -related origin of the organ, we used epidermal growth factor (EGF-r), transforming growth factor (TGF-alpha) and nerve growth factor (NGF-beta) immunohistochemical stains. Results: We observed a very strong and 'widespread immunoreactivity of EGF-r and TGF-a on simple squamous capsular cells. We detected nerve growth factor-beta positivity in granular form both in simple squamous capsular cells and in neighboring connective tissue. However, we did not detect EGF-r reactivity on parenchymal cells except a weak immunoreactivity on central ones. We noticed transforming growth factor-a in most of the parenchymal cells while we observed NGF-beta strongly in all the parenchymal cells. Conclusion: These results may point out that the JOO may be of mesothelial or epithelial origin. Having NGF-alpha. positive granules and close relationship with blood vessels may imply a neurosecretory function. We believe that our study may add new perspectives to the function of the JOO.