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  • Küçük Resim
    Öğe
    Desmoplastic Small Round-Cell Tumor in a Dog
    (2018) Alçığır, Mehmet Eray; Kutlu, Tuncer; Çolakoğlu, Ekrem Çağatay; Dinç, Ceyda
    A 13-year-old, neutered female Husky dog was brought to the clinic with the complaints of anorexia, vomiting, abdominal distension and respiratory distress. It was suddenly died during intervention. At the necropsy, a mass was seen in the abdominal cavity. The mass had 16x15x9 cm in diameters. Histological examination revealed clusters of cells with slightly eosinophilic and scanty cytoplasm, small round hyperchromatic nuclei, and inconspicuous nucleoli encompassed by hypocellular extensive desmoplastic connective tissue stroma comprising few spindle-shaped connective tissue cells. In immunohistochemical examination the cytoplasms of tumour cells were detected to be mildly positive by nestin. The tumour cells were negative for ?-SMA (Alpha-Smooth Muscle Actin), vimentin and pancytokeratin, but stromal cells were positive for ?-SMA and vimentin. Despite the presence of partially incompatible immunohistochemical findings, the tumor in this case was diagnosed as desmoplastic small round-cell tumor because its aggressiveness, localization, and histopathology was similar to that observed for this tumor in humans. Previously this tumor has not been identified in animals.
  • Küçük Resim
    Öğe
    Postmastectomy life-threatening hypersensitivity reactions induced by rifamycin sv in companion animals: Evaluation of 7 cases
    (Ataturk Universitesi, 2018) Çolakoğlu, Hatice Esra; Polat, İbrahim Mert; Yazlık, Murat Onur; Çolakoğlu, Ekrem Çağatay
    Drug-induced hypersensitivity and adverse symptoms related to the high mortality remain as a major problem for veterinary practitioners. Although application of Rifamycin SV without intradermal susceptibility tests have been commonly used in wound management in veterinary medicine, there is no literature about this subject. In cases presented here, neoplastic masses on the mammary glands of queens (n=3) and bitches (n=4) were removed by mastectomy. Subcutaneous Rifamycin SV was performed intra- and post-operatively. After the multiple subcutaneous usage of Rifamycin SV, acute symptoms including hypersensitivity reactions such as facial and sublingual swelling, hypersalivation, respiratory distress, tachycardia, acute vomiting, erythema and itchiness around the face, seizures and ataxia developed. In conclusion, although Rifamycin SV provides better healing effects on incision line, veterinary practitioners should consider the serious side effects of subcutaneous Rifamycin SV usage after gynaecological surgeries in companion animals. © 2016 Ataturk Universitesi. All rights reserved.