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  • Küçük Resim
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    Corneal thickness and endothelial changes in long-term hydroxychloroquine use
    (Taylor & Francis Ltd, 2019) Oğurel, Tevfik; Özer, Murat Atabey; Akbulut, Yaprak; Gökçınar, Nesrin Büyüktortop; Onaran, Zafer; Üreten, Kemal
    Objective: To determine possible associations between long-term HCQ use and corneal changes in patients who used HCQ for at least 3 years. Materials and methods: The study included 62 healthy controls and 62 consecutive patients who used HCQ for the treatment of rheumatologic disease and were referred to the ophthalmology department between August 2018 and November 2018 for HCQ retinal toxicity screening. Central corneal thickness (CCT), corneal endothelial cell density (ECD), the coefficient of variation (CV) of cell size, and the percentage of hexagonal cells (HEX%) were measured to evaluate changes in the cornea. Results: The mean age of the patient group and control group was 50.10 +/- 10.91 and 50.53 +/- 10.67 years, respectively. The mean ECD was 2742 +/- 347 (cells/mm(2)) in the patient group and 2875 +/- 188 cells/mm(2) in the control group. There was a significant difference between groups (p = 0.01). The mean CCT was 567.05 +/- 32.35 mu m in the patient group and 540.15 +/- 38.50 mu m in the control group. CCT was significantly higher in the patient group compared with control group (p < 0.001). There was no significant difference between groups in terms of mean CV and HEX values (p > 0.05). Conclusions: Patients using long-term HCQ demonstrated lower ECD and higher CCT than the control group. However, the CV of cell sizes and the HEX % values were not significantly different from the controls.
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    Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes
    (Springer, 2017) Özer, Murat Atabey; Polat, Nihat; Özen, Serkan; Oğurel, Tevfik; Parlakpinar, Hakan; Vardi, Nigar
    The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.
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    Mini-mental state exam versus Montreal Cognitive Assessment in patients with diabetic retinopathy
    (Medknow Publications & Media Pvt Ltd, 2015) Oğurel, Tevfik; Oğurel, Reyhan; Özer, Murat Atabey; Türkel, Yakup; Dag, Ersal; Örnek, Kemal
    Background: Mini-mental state exam (MMSE) was used several times but no study has examined cognition on the Montreal Cognitive Assessment (MoCA) in diabetes and diabetic retinopathy (DR). In this study, we compared MMSE with MoCA in patients with DR and searched for an association between the severity of DR and cognitive impairment (CI). Methods: This cross-sectional study comprised 120 consecutive patients with diabetes. Patients were divided into four groups as no DR, mild DR, severe nonproliferative DR (PDR) and PDR. Each group consisted 30 inviduals. CI was assessed using the MMSE and MoCA. Results: The number of subjects with a score > 21 were significantly lower on the MoCA than on the MMSE between groups (all P < 0.05). The mean MoCA score was significantly lower than the MMSE score (P < 0.001) There was a linear association between the grade of DR and a score < 21 on both tests. Conclusion: MoCA provides more insight into the cognitive function in DR.