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    Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2023) Kul, Bengi Çınar; Bilgen, Nuket; Biskin, Merve; Akkurt, Mustafa Yenal; Çıldır, Özge Şebnem; Özmen, Özge; Kul, Oğuz
    Mammals have physiological reprogramming adaptation ability to changing seasonal light and temperature, through their biological clocks maintained by circadian rhythm, photoperiodism and thermoperiodism. Seasonal differences do not only affect vital activities of animals like migration, reproduction, and sleeping, but also cause dramatic changes in their economically important characteristics (e.g. fur quality and fattening level). Mohair is constituted of non-medullary hairs produced by secondary hair follicles in Angora goats and the effects of seasonal differences on mohair structure and related genes are still unknown. We examined the gene expression levels of BMP-2, FGF-5, HOXC13, KAP9.2 and TGFBR2 normalized with GAPDH in skin biopsies taken from Angora goats (n=20) in two different follicle development stages; telogen (in February) and anagen (in June). HOXC13 showed overexpression in anagen phase (P<0.005) whereas expression was undetectable in telogen phase. BMP-2 (P<0.005), FGF-5 (P<0.005) and TGFBR2 (P<0.01) were significantly upregulated in anagen, while KAP9.2 expression showed no difference between two phases. This is the first study on hair follicle-related genes in the angora goat. Additionally, depending the role of HOXC13 in pathways, it suggests that its overexpression may be one of the main factors associated with the non-medullary hair structure in Angora goats.
  • Küçük Resim
    Öğe
    Transcriptome analysis and potential mechanisms of bovine oocytes under seasonal heat stress
    (Taylor & Francis Inc, 2023) Özmen, Özge; Karaman, Kardelen
    Heat stress is the major factor affecting cattle fertility but molecular mechanisms of deleterious impacts of elevated temperature on oocyte are still not well known. Therefore, the aim of this study is to gain a better understanding of the underlying molecular mechanism of how heat stress affects GV-stage and MII-stage oocytes and discover hub genes to heat resistance for cow oocytes. In this study, we used the bioinformatics approach to discover the differentially expressed genes between GV-stage and MII-stage oocytes, which were collected during spring and summer. When GV-stage oocytes were compared to MII-stage oocytes collected in July (Jul DEGs group) a total of 1068 genes were found as differentially expressed as a result of heat stress. Also, HSPA8, COPS5, POLR2L, PSMC6, and TPI1 were identified as the common top ranked genes for the Jul DEGs group. The highest connected hub gene for the Jul DEGs group was determined as HSPA8. Our results showed that different heat response mechanisms might be activated to protect oocytes from elevated temperatures in cattle. The identified genes and their associated pathways might play an important role in the response to heat stress that affects the oocytes in cattle.