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Öğe Can curcumin modulate allergic rhinitis in rats?(Cambridge Univ Press, 2016) Acar, M.; Muluk, N. Bayar; Yigitaslan, S.; Cengiz, B. P.; Shojaolsadati, P.; Karimkhani, H.; Cingi, C.Objectives: This study aimed to explore the effects of curcumin on experimental allergic rhinitis in rats. Methods: Twenty-eight male Wistar albino rats were randomly divided into four groups: a control group; a group in which allergic rhinitis was induced and no treatment given; a group in which allergic rhinitis was induced followed by treatment with azelastine hydrochloride on days 21-28; and a group in which allergic rhinitis was induced followed by treatment with curcumin on days 21-28. Allergy symptoms and histopathological features of the nasal mucosa were examined. Results: The sneezing and nasal congestion scores were higher in the azelastine and curcumin treatment groups than in the control group. Histopathological examination showed focal goblet cell metaplasia on the epithelial surface in the azelastine group. In the curcumin group, there was a decrease in goblet cell metaplasia in the epithelium, decreased inflammatory cell infiltration and vascular proliferation in the lamina propria. Conclusion: Curcumin is an effective treatment for experimentally induced allergic rhinitis in rats.Öğe Comparison of Physical Activity Levels in Rheumatic Diseases(Georg Thieme Verlag Kg, 2017) Acar, M.; Tonga, E.; Daskapan, A.; Karatas, M.; Tekindal, A.Objectives The aim of this study was to evaluate levels of physical activity in patients with rheumatoid arthritis, osteoarthritis and fibromyalgia and to compare the results with both healthy subjects and each other. Methods A group of 50 rheumatoid arthritis patients, 95 osteoarthritis patients, 82 fibromyalgia patients and 110 healthy subjects were included in this study. Physical activity levels were assessed by the International Physical Activity Questionnaire (IPAQ). Results There were significant differences in walking and total physical activity scores in IPAQ between the rheumatoid arthritis (RA), osteoarthritis (OA), fibromyalgia (FMS) patients and the control group (p < 0.05). 36.6 % of the fibromyalgia group, 28.4 % of the osteoarthritis group, 38 % of the rheumatoid arthritis group and 22.7 % of the healthy subjects were found to be inactive. 45.1 % of the fibromyalgia group, 42.1 % of the osteoarthritis group, 46 % of the rheumatoid arthritis group and 36.4 % of the healthy subjects were found to be insufficiently active. Conclusion As a result, when compared to healthy people, physical activity levels were significantly decreased in patients with rheumatoid arthritis, osteoarthritis, fibromyalgia. The decreases in the physical activity levels were clearer in patients with rheumatoid arthritis than in patients with osteoarthritis and fibromyalgia. Recommending regular physical activity should be integral to rheumatic disease management and walking offers a potentially accessible, inexpensive, and acceptable physical activity intervention.Öğe Physical activity level and physical fitness in patients with rheumatoid arthritis(Bmj Publishing Group, 2013) Acar, M.; Tonga, E.; Daskapan, A.…Öğe Physical Inactivity in adults with rheumatic diseases(Bmj Publishing Group, 2014) Tonga, E.; Acar, M.; Daskapan, A.…Öğe Potential protective effect of resveratrol on acoustic trauma: electron microscopy study(Verduci Publisher, 2016) Hanci, D.; Ulusoy, S.; Acar, M.; Burukoglu, D.; Kutlu, H. M.; Muluk, N. Bayar; Cingi, C.OBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group 1 (Control, n = 6), Group 2 (AT, n = 6), and Group 3 (resveratrol + AT). The rats in Group 2 were exposed to AT. The rats in Group 3 received resveratrol (300 mg/kg/day) via gavage for 7 days. On day 7, the rats were exposed to AT 10 min following resveratrol treatment. Histological sections of the cochleae were examined using light microscopy, transmission (TEM), and scanning electron microscopy (SEM). RESULTS: The cochlear hair cells, stereocilia, and Deiters' cells of the control group appeared normal in all microscopic evaluations. In Group 2, light microscopy revealed predominantly inner hair cell loss, although the outer hair cells were affected. TEM and SEM examination showed severe loss of stereocilia and SEM revealed stereocilia arranged in an asymmetric array. The cochlear structure in Group 3 appeared well preserved under the light microscope, and although TEM and SEM revealed stereocilia loss, the hair cells and stereocilia appeared near normal compared with those of Group 2. CONCLUSIONS: Resveratrol may have a protective effect against AT damage in the cochlea, most likely through its antioxidant activity. Our results may be useful for studies in humans exposed to AT and noise-induced hearing loss related to chronic exposure to occupational noise.
