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Öğe Lamotrigine induced seizures in juvenile myoclonic epilepsy(2013) Acar B.; Dağ E.; Türkel Y.Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome. Before the development of the new antiepileptic drugs (AEDs) after the 1990s, Valproate (VPA) was the first-line treatment in juvenile myoclonic epilepsy. However, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. Lamotrigine (LTG), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. We report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (GTC) seizures after decreasing the lose of VPA and initiating LTG. © 2013 OMU.Öğe Rare side effects of valproic acid: Gingival hyperplasia, and cervical lymphadenopathy(2013) Dağ E.; Demirer S.; Gökçe B.; Acar B.; Keçel H.G.; Aylikçi U.B.; Erdemoğlu A.K.Gingival hyperplasia is a common disorder seen in patients with epilepsy treated with phenytoin. It is rarely seen in patients taking sodium valproate therapy. Especially in mentally retarded patients, poor oral hygiene causes to the accumulation of bacterial plaque and inflammation might be occurs. Connective tissue increases due to inflammation and gingival hyperplasia is seen. We report a case of gingival hyperplasia due to valproic acid use to draw attention to rare adverse effect of this drug.Öğe Refractory status epilepticus that responded to steroid application(Duzce University Medical School, 2013) Dağ E.; Acar B.; Kasimcan O.; Erdemoğlu A.K.The minimum duration of a seizure needed to be described as status epilepticus is a matter of great debate; but many authors use a time period of 5 to 20 minutes. In refractory status epilepticus, despite treatment with conventional antiepileptic drugs, seizures continue or baseline values of consciousness between seizures do not return. Status epilepticus due to a brain tumor may be resistant to antiepileptic therapy. A case of refractory status epilepticus controlled by steroid application is presented in this report and discussed in the light of literature. © 2013 Düzce Medical Journal.