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    Lamotrigine induced seizures in juvenile myoclonic epilepsy
    (2013) Acar B.; Dağ E.; Türkel Y.
    Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome. Before the development of the new antiepileptic drugs (AEDs) after the 1990s, Valproate (VPA) was the first-line treatment in juvenile myoclonic epilepsy. However, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. Lamotrigine (LTG), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. We report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (GTC) seizures after decreasing the lose of VPA and initiating LTG. © 2013 OMU.
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    Rare side effects of valproic acid: Gingival hyperplasia, and cervical lymphadenopathy
    (2013) Dağ E.; Demirer S.; Gökçe B.; Acar B.; Keçel H.G.; Aylikçi U.B.; Erdemoğlu A.K.
    Gingival hyperplasia is a common disorder seen in patients with epilepsy treated with phenytoin. It is rarely seen in patients taking sodium valproate therapy. Especially in mentally retarded patients, poor oral hygiene causes to the accumulation of bacterial plaque and inflammation might be occurs. Connective tissue increases due to inflammation and gingival hyperplasia is seen. We report a case of gingival hyperplasia due to valproic acid use to draw attention to rare adverse effect of this drug.