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    Electrospun nanofiber drug delivery systems and recent applications: An overview
    (Elsevier, 2024) Muratoglu, Semsi; Inal, Murat; Akdag, Yagmur; Gulsun, Tugba; Sahin, Selma
    Fiber technology plays a significant role in advancing drug research. While developing drug delivery systems, nanofiber technology has gained importance due to its high surface area to volume ratio and porosity. The most preferred nanofiber production method is the electrospinning method. This review focuses on electrospun nanofiber drug delivery systems, including analysis of critical process parameters affecting electrospinning and nanofiber properties. Moreover, the design strategies for nanofiber drug delivery systems are explored, including equipment preferences and design types. Given to these design strategies, it is possible to design either nanofiber mat or nanofiber itself. It has been shown that a tailor-made drug delivery system can be prepared using axialbased nozzles and other equipment options. In addition, the prominent features and usage areas of frequently used polymers are mentioned. General characterization studies of post-production nanofibers are discussed. Examples of areas of use for pharmaceutical purposes are presented. Finally, drug release kinetics were evaluated on electrospun nanofiber drug delivery systems. As a result of exhaustive evaluations, various effective applications in the literature have been shown to achieve remarkable results such as drug release manipulation, drug targeting, self-assembling formulation strategies. Therefore, it is clear that in the field of electrospun nanofiber technology, it is possible to modify all the process options and develop a unique drug delivery product, thanks to a comprehensive evaluation of the critical quality parameters of the drug product.
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    Öğe
    The development and characterization of electrospun gelatin nanofibers containing indomethacin and curcumin for accelerated wound healing
    (Elsevier, 2022) Gulsun, Tugba; Inal, Murat; Akdag, Yagmur; Izat, Nihan; Oner, Levent; Sahin, Selma
    Nanofibers are frequently investigated to facilitate wound healing. In this study, gelatin nanofibers were produced that are biodegradable and biocompatible. Indomethacin and curcumin were added to the formulation to add antioxidant, anti-inflammatory, analgesic properties to the nanofibers. The nanofibers were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR). Cell viability, proliferation, tensile strength, content uniformity, antioxidant activity, drug release studies were investigated. DSC and FTIR analyses showed that indomethacin and curcumin were coated with the gelatin in the nanofibers. SEM studies demonstrated that smooth and homogeneous nanofibers were produced in the range 260-360 nm. Tensile strength values decreased with the addition of indomethacin and curcumin to the gelatin nanofiber, while the antioxidant activity results showed that the wound dressings can remove reactive oxygen species. There was no significant decrease in cell viability as a result of adding indomethacin and curcumin to the nanofibers. It was predicted that with a rapid release of indomethacin from the nanofibers, an analgesic effect will be obtained first and then an antioxidant effect will be seen from the longterm release of curcumin. Consequently, it was shown that the nanofibers produced can be used safely and effectively as an antioxidant wound dressing material.