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Total testosterone, cortizol, growth hormone and fluorine levels in fluorine intoxicated rabbits
(Scientific Technical Research Council Turkey, 2001) Akdoğan, M.; Bilgili, A.; Kaya, S.; Yarsan, E.; Üstüner, E.
In this study, the effects of fluorine given subchronically (70 days) in drinking water (1, 10, 40 mg/L) were assessed in New Zealand male rabbits and their effects on total testosterone, cortisol and growth hormone (GH) levels were determined. Blood samples were taken from control and experimental groups after 0, 21 and 70 days and total testosterone, cortisol, GH and fluorine levels were measured. As a result, in animals given 10 mg/L fluorinated water, on the 21(st) day there was a statistically significant (p<0.01) drop in the cortisol levels and it was found that the drop in the testosterone levels and the rise in the GH levels were statistically insignificant. In animals given 10 mg/L fluorinated water, the drops in the cortisol and GH levels on the 70(th) day were statistically significant (p<0.01). in animals given 40 mg/L fluorinated water, the drops in the cortisol and GH levels on the 21(st) day were statistically significant (p<0.01). Also, on the 70(th) day the drop in the testosterone levels was statistically significant (p<0.05) and the drop in the cortisol and GH was very significant (p<0.001). Fluorine levels significantly rose during the study (p<0.001). depending on the species, doses and duration of application.