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    Can Resistin be a New Indicator of Neonatal Sepsis? (conferenceObject)
    (Wiley-Blackwell Publishing, Inc, 2009) Aliefendioglu, D.; Gursoy, T.; Caglayan, O.; Hayran, M.; Aktas, A.; Ovali, H. F.
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    Comparison of the Mechanical Properties of Platelet-Rich Fibrin and Ankaferd Blood Stopper-loaded Platelet-rich Fibrin
    (Wolters Kluwer Medknow Publications, 2018) Aktas, A.; Ozer, T.; Sen, M.; Turk, M.; Karabulut, E.
    Background and Aim: Platelet-rich fibrin (PRF) can be named as a natural fibrin-based biomaterial favorable to increasing vascularization and able to guide epithelial cell migration to its surface. The membrane has a significant positive effect on protecting open wounds and accelerating healing. Similar to PRF Ankaferd Blood Stopper (ABS) also has positive effects on wound healing. The aim of this study was to detect if we can improve known physical properties of PRF combining with ABS. This idea was based on the known mechanism of ABS in forming protein network without damaging any blood cells. Materials and Methods: A total of 25 adult rabbits used for collecting 5-7 ml of blood passively with the help of winged blood collection needle to the test tube. Collected samples were centrifuged at 3000 rpm for 10 min. Two similar samples obtained from each animal and one of the samples was placed in 20% ABS 80% saline solution for 5 min. Mechanical properties of the membrane samples were measured using Universal Testing Machine. Results: There is the statistically significant difference between PRF and ABS added PRF in elongation/mm (dL) and elongation/% at break values. Maximum force (fMax) and modulus values did not show any statistically significant differences. Conclusion: ABS loaded PRF causes better physical properties. This combination seems to exhibit superior performance when used as a membrane barrier solely. Advanced studies can be done on biological properties of ABS loaded PRF, especially on tissue healing.
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    Resistin levels in preterms: are they influenced by fetal inflammatory course?
    (Nature Publishing Group, 2011) Gursoy, T.; Aliefendioglu, D.; Caglayan, O.; Aktas, A.; Ovali, F.
    Objective: Many different factors are involved in the pathogenesis of preterm deliveries and among them maternal or perinatal infections and inflammatory response have the major role. Researches were carried out about resistin, which is thought to have a role in inflammatory cytokine cycle and it was shown to be associated with growth in neonates. However, no research has been carried out showing its relationship with inflammation in neonates. In this study, we aimed to evaluate the resistin levels in premature neonates and the effect of events such as preterm prelabour rupture of the membranes (PPROMs) and the use of antenatal steroids on these levels. Study Design: The study included 118 preterm neonates. Their medical data together with their mothers' were recorded. Serum resistin levels together with interleukin (IL)-6, C-reactive protein (CRP) and procalcitonin were evaluated in the first 2 h of life. Result: Mean gestational age and birth weight of babies included in the study were 29.6 +/- 2.7 weeks and 1306.4 +/- 393.4 g, respectively. Babies with PPROMs had significantly higher levels of resistin ((n = 30); 70.7 (7.8 to 568.4) ng ml(-1)) than babies without PPROM ((n = 88); 25.9 (5.5 to 528.9) ng ml(-1)) (P = 0.005), and the babies of mothers who received antenatal steroids had significantly lower resistin levels ((n = 44); 20.8 (5.5 to 159.9) ng ml(-1)) than the babies of mothers who did not ((n = 66); 34.6 (7.2 to 568.4) ng ml(-1)) (P = 0.015). There were significant correlations between resistin and IL-6 levels and between IL-6 and procalcitonin and CRP levels in babies whose mothers did not receive antenatal steroids. However, no correlation was found between these parameters in babies whose mothers received antenatal steroids. Conclusion: Preterm delivery and PPROM involve complex cascade of events including inflammation, and steroids are potent anti-inflammatory agents. Elevated resistin levels in babies with PPROM and suppressed levels in babies whose mothers received antenatal steroids reported in this study might have been observed as a result of the effects of fetal inflammation on resistin levels. Journal of Perinatology (2011) 31, 171-175; doi:10.1038/jp.2010.103; published online 5 August 2010
  • [ X ]
    Öğe
    Resistin levels in preterms: Do they influence fetal inflammatory course?
    (Wiley-Blackwell Publishing, Inc, 2009) Gürsoy, T.; Aliefendioglu, D.; Caglayan, O.; Aktas, A.; Ovali, H. F.
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