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    Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles
    (Elsevier Science Bv, 2019) Isiklan, Nuran; Altinisik, Zeynep
    Temperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.
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    Temperature-responsive alginate-g-poly(N,N-diethylacrylamide) copolymer: Synthesis, characterization, and swelling behavior
    (Wiley, 2018) Isiklan, Nuran; Altinisik, Zeynep
    Temperature-responsive polymers have recently gained importance due to their applications in drug delivery. Herein, temperature-responsive graft copolymer (Alg-g-PDEAAm) of alginate and N,N-diethylacrylamide was synthesized by microwave-assisted copolymerization using potassium persulfate/N,N,N,N-tetramethylethylenediamine initiator system. The reaction conditions for the best grafting (331%) have been optimized by changing microwave irradiation time, temperature, N,N-diethylacrylamide, and alginate concentrations. The spectroscopic characteristic, thermal properties, and surface morphology of the copolymers were investigated by FTIR, H-1-NMR, DSC/TGA, XRD, gel permeation chromatography, and SEM. Furthermore, low critical solution temperatures of Alg-g-PDEAAm copolymers were detected by UV spectroscopy. Swelling ratio of graft microspheres was carried out at 25, 32, and 37 degrees C, and microspheres were found exhibiting temperature-responsive property. Cytotoxicity test indicated the Alg-g-PDEAAm copolymer and its microsphere were biocompatible. Therefore, based on the results the synthesized temperature-responsive copolymer could be considered as a promising biomaterial. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46688.