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    Hereditary haemochromatosis gene (HFE) H63D mutation shows an association with abnormal sperm motility
    (Springer, 2009) Gunel-Ozcan, Aysen; Basar, M. Murad; Kisa, Ucler; Ankarali, Handan C.
    The aim of this study was to screen infertile men for HFE H63D mutation in correlation with clinical characteristics of infertile men (sperm concentration, sperm motility, morphology, testicular volume, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and total Testosterone levels) and find out if the HFE H63D mutation has an effect on male infertility. After excluding hormonal treatment, any scrotal pathology, having any systemic diseases such as diabetes mellitus, sickle cell anemia and microdeletions of the Y chromosome, a total of 148 infertile men with age range between 17 and 52-years-old (average age 29.6 +/- A 7.2) were enrolled into the study. Our analysis indicates that the mean FSH levels are significantly higher (6.3 +/- A 4.6 mIU/ml, P = 0.03), whereas sperm motility is significantly lower (36.6 +/- A 28.1%, P = 0.01) in the infertile men with the HFE H63D mutation compared with subjects lacking this mutation. Comparison of allele frequencies of the infertile men with Ts < 50% versus the infertile men with Ts > 50% revealed a significant difference as expected (P = 0.001, OR = 0.14, %95 CI = 0.04-0.44). Comparison of allele frequencies of infertile men with abnormal sperm motility versus infertile men with normal sperm motility revealed a highly significant difference (P = 0.005, OR = 3.11, %95 CI = 1.41-6.86). Thus, the HFE H63D mutation seems to be an important risk factor for impaired sperm motility and is clinically associated with male infertility.
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    Medico-Legal Evaluation of Adolescent Parricide Offenders: Thirty Nine Cases from Turkey
    (Springer/Plenum Publishers, 2011) Buyuk, Yalcin; Kurnaz, Gulay; Eke, S. Murat; Ankarali, Handan C.; Oral, Gokhan
    Parricide which is defined as the murder of one's parents is a rare event. We describe a consecutive series of adolescent parricide offenders referred to the Council of Forensic Medicine for medico-legal evaluation. Majority of the adolescent parricide offenders were male with a frequency of 79.5%. Age of the offenders ranged from 12 to 18 years old with a median age of 15.13. The majority of the victims were the fathers of the offenders (27; 69.2%). Firearms and cutting devices were the most frequently used weapons. The history of abuse in the family as a motive for the murder was detected in 51.2% of the offenders. The major abuse type was physical abuse. There was no history of psychiatric disorders in the majority of the offenders (37; 94.9%). After the medico-legal evaluation of the adolescent parricide offenders in the Council of Forensic Medicine, psychiatric disorder was diagnosed only in 4 offenders. Schizophrenia was the final diagnosis in 3 cases and paranoid disorder (otherwise unclassified) in only 1 offender. Our study confirmed the frequency of mental illness among adolescent parricide offenders to be very low when compared to adult offenders. Adolescent parricide offenders differ from the other perpetrators particularly in terms of motives of the murder and psychiatric illnesses. Abuse in the family seems to play an important role in these murders. Therefore, it is extremely important that individuals in the legal, criminal justice, social work, psychology, educational and other professional communities be more conscious and informed of child maltreatment and family violence and more research is essential in understanding and preventing adolescent parricide offenders.