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    Antimicrobial effectiveness of silicone oil, heavy silicone oil and perfluorodecaline against Bacillus cereus
    (Kluwer Academic Publishers, 2014) Örnek N.; Apan T.; Örnek K.; Günay F.
    The purpose of this work is to study the effectiveness of silicone oil, heavy silicone oil and perfluorodecaline against Bacillus cereus. For this we tested the antimicrobial activities of three intraocularly used liquids-silicone oil (Siluron 1000), heavy silicone oil (Densiron-68) and perfluorodecaline (F-Decalin)-against B. cereus (NCTC 9946). The antimicrobial effects of silicone oil, heavy silicone oil and perfluorodecaline were determined by the growing capability of the microorganism. We found that the number of B. cereus decreased in all three concentrations of silicone oil. The bacteria grew for approximately 2 weeks in heavy silicone oil and declined after 17 days. Perfluorodecaline significantly reduced B. cereus colonies and was the most effective of the liquids. In conclusion, silicone oil and perfluorodecaline seem to be effective against B. cereus. © 2013 Springer Science+Business Media.
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    The antimicrobial susceptibility of Moraxella species other than Moraxella catarrhalis
    (Turkiye Klinikleri, 2015) İşeri L.; Apan T.; Şahin E.
    Objective: Although Moraxella species are members of the normal respiratory flora, some species, including M. catarrhalis, M. osloensis, M. nonliquefaciens, and M. lacunata, can cause serious infections in humans. The purpose of this study was to investigate the antimicrobial susceptibility of Moraxella species other than M. catarrhalis. Material and Methods: The study included 17 M. osloensis, 18 M. lincolnii, and three M. nonliquefacie, isolated from 100 nasopharyngeal samples. The isolates were identified by conventional methods. Identification to the species level was performed by a RapID NF Plus identification kit (Remel, USA). The antimicrobial susceptibility of the isolates was examined for ampicillin, amoxicillin/clavulanic acid, gentamicin, ceftazidime, ciprofloxacin, erythromycin and trimethoprim-sulfamethoxazole using the disk diffusion method. The results were evaluated according to guideline published by the Clinical and Laboratory Standards Institute. ?-Lactamase production was tested using nitrocefin discs. Results: The resistance rates of isolates were between 3% and 8% for trimethoprim-sulfamethoxazole, amoxicillin/clavulanic acid. Inhibition zone diameters for ampicillin of 41% of M. osloensis, 33% of M. nonliquefaciens, and 11% of M. lincolnii isolates were relatively small (?15 mm). Five M. osloensis (29%) and one M. nonliquefaciens, isolates were beta lactase positive. Conclusion: Moraxella species other than M. catarrhalis can cause serious infections in humans. Therefore, we suggest that Moraxella species other than M. catarrhalis should be included in surveillance studies. © 2015 by Türkiye Klinikleri.
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    Comparison of the antimicrobial effect of heavy silicone oil and conventional silicone oil against endophthalmitis-causing agents
    (Medknow Publications, 2014) Örnek N.; Apan T.; Oğurel R.; Örnek K.
    Purpose: To conduct an in vitro experimental study comparing the effectiveness of conventional silicone oil and heavy silicone oil against endophthalmitis-causing agents. Materials and Methods: The antimicrobial activity of conventional silicone oil (RS OIL 5000) and heavy silicone oil (heavySil 1500) was tested. The antimicrobial effects of both silicone oils were determined by the growing capability of the microorganism. Results: The number of Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans decreased to zero levels at the second day of inoculation in heavy silicone oil. In conventional silicone oil, the microorganisms survived longer than in heavy silicone oil. Conclusion: Heavy silicone oil seems to be more effective than conventional silicone oil against endophthalmitis-causing agents. © 2005 - Indian Journal of Ophthalmology.
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    Investigation of antibacterial activity of drugs used in enuresis treatment
    (Logos Medical Publishing, 2012) Boybeyi Ö.; Apan T.; Günal Y.D.; Aslan M.K.; Soyer T.
    Objective: An in vitro study was designed to evaluate the antibacterial activity of desmopressin (DP), oxybutynin (OX), imipramine (IP), and doxazosin (DX), which are used commonly in enuresis treatment. Material and Methods: To investigate the antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis; the drugs were dispensed to tubes with physiologic saline (PS) or brain-heart broth (BHB). BHB was followed for 6 days and PS for 20 days. Antibacterial activity was examined using in vitro Time-kill method. Bacteria colonies were counted daily from PS and BHB media as colony-forming units (CFU) and evaluated by bacteri-growth graphs. Results: In BHB, none of the drugs affected growth of any bacteria. In PS, E. coli growth increased initially with DP, DX and IP and then decreased on the 5th day. Growth of E. coli was seen to continue in PS without drug on the 5th day. For DX and IP, S. epidermidis growth in PS first increased then decreased. In all PS media, growth of P. aeruginosa was seen to increase gradually. Conclusion: DP, DX and IP decreased growth of E. coli in PS, but did not prevent bacterial growth completely. Drugs used in enuresis treatment have no antibacterial activity for the bacteria evaluated in the current study. © Cocuk Cerrahisi Dergisi. All rights reserved.