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  • Küçük Resim
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    The effects of some macroalgae on viability of Drosophila melanogaster
    (Ege Univ, 2017) Arica, Sukran Cakir; Demirci, Sevil; Ozyilmaz, Ayse; Oz, Selda; Arslantas, Ecem
    The aim of this study is to investigate the effects of three different macroalgae (Codium sp., Cystoseira sp., and Polyides sp.) on viability of Drosophila melanogaster which is the most widely studied insect species in scientific researches. One of the primary reasons why Drosophila melanogaster is one of so widely studied insect is because of their extremely fast breeding rate in a very short time. Compared to other laboratory animals, the Drosophila melanogaster gene pattern is one of the most widely understood. This may allow some modifications to be made with a very good survival rate. Once these basic functions are completed, the insect hatches and develops into a larval form and stars feeding. At this point, the larvae are feed with what kind of feed want to be tested. In this current study, extracts of macroalgae, Codium sp., Cystoseira sp., and Polyides sp., were added into Instant Drosophila Medium Formula 4-24 and given the Drosophila melanogaster in three groups. There was also a fourth group (control group) which is not added extracts of macroalgae in their feed but water. The results of this study showed that macroalgae, Codium sp., Cystoseira sp., and Polyides sp., had positive effects on viability of Drosophila melanogaster.
  • Küçük Resim
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    The Genoprotective Effect Of Crocus Sativus L. (Saffron) Extract On Doxorubicin-Induced Genotoxicity In Drosophila Melanogaster
    (Parlar Scientific Publications (P S P), 2019) Oz, Selda; Arica, Sukran Cakir
    Crocus sativus L. (saffron) is a medicinal plant that has been used for the prevention and treatment of various diseases since ancient times. Saffron also has a distinctive aroma and is used as a food coloring, in addition to its therapeutic effects. In this study the genotoxic and antigenotoxic impacts of saffron were evaluated using the somatic mutation and recombination test (SMART). Doxorubicin, a chemotherapeutic drug, was used as a genotoxic agent to evaluate the antigenotoxic activity of saffron. Transheterozygous larvae obtained from a standard cross between flare WO and multiple wing hair (mwh) mutant strains of Drosophila melanogaster were treated with the test materials. Saffron extract was applied at three different concentrations (1,5 and 10 mg/mL) to evaluate any genotoxic effect. In the antigenotoxic assessment, each dose of the saffron extract was co-administered with doxorubicin (0.125 mg/mL). The data obtained from our study indicated that the ethanol extract of saffron did not show any genotoxic effect but instead exerted a powerful protective effect against the genotoxic effect of doxorubicin that was dose dependent.