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    Association of physical activity and obesity status for individuals between the ages of 18-30 via bioelectrical impedance analysis device and metabolic holter measurements
    (Mattioli 1885, 2017) Aksoy, Aziz; Selen, Halime; Ozdemir, Fethi Ahmet; Arikan, Funda Bulut
    Obesity, according to its simplest definition, is excessive accumulation of fat in the body. Obesity is a health problem that is observed commonly in almost all societies and it is starting to become a global epidemic. In this study, physical activity and obesity statuses for individuals between the ages of 18-30 with different body types were tried to be associated via bioelectrical impedance analysis device and metabolic holter measurements. It was determined according to the results of the study that body fat ratio increases and number of steps decreases with increasing age, that there are statistically significant differences between gender and AEC, TEC, muscle weight and total body water and that this ratio is greater in men in comparison with women. Statistically significant differences (P<0.05) were determined between the muscle weight and total body water, BMI,waist/hip ratio, TEC, AEC; between total body water and BMI, waist/hip ratio, TEC and AEC; between the body mass index of individuals and their body fat ratio, waist/hip ratio, TEC and AEC; between body fat ratio and waist/hip ratio and TEC; betwen waist/hip ratio and TEC and BMR; total energy consumption and physical activity duration, AEC, number of steps, PAL, time spent with moderate intensity movement and time spent with very high intensity movement; physical activity levels and AEC, number of steps, PAL, time spent with moderate intensity movement and time spent with high intensity movement; between active energy consumption and number of steps, PAL, time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement; number of steps and PAL, time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement; PAL values of individuals who participated in the study and the time spent with moderate intensity movement, time spent with high intensity movement and time spent with very high intensity movement.
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    Effects of acute aerobic exercise on cytokines, klotho, irisin, and vascular endothelial growth factor responses in rheumatoid arthritis patients
    (Springer London Ltd, 2023) Ercan, Zubeyde; Deniz, Gulnihal; Yentur, Songul Baglan; Arikan, Funda Bulut; Karatas, Ahmet; Alkan, Gokhan; Koca, Suleyman Serdar
    Background Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes cartilage and bone damage as well as disability. Aims The aim of this study was to examine the effects of acute aerobic exercise on cytokines such as serum interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), Tumor Necrosis Factor-alpha (TNF-alpha) and irisin, vascular endothelial growth factor(VEGF) and klotho in RA patients. Methods Forty RA patient and 40 healthy volunteers of the same age participated in this study. All participants walked on the treadmill for 30 minutes at 60-80% of maximal heart rate. Blood samples were taken before and immediately after the exercise. Serum levels of IL-6, IL1 beta, TNF-alpha and irisin, VEGF and klotho were measured by enzyme-linked immunosorbent analysis. Results Baseline levels of inflammatory cytokines, irisin, VEGF and klotho were found to be higher in RA patients compared to the control group. In both groups, there was an increase in serum klotho levels after exercise compared to baseline (p<0.05), while a decrease in IL1 beta, TNF-alpha levels were observed. While serum VEGF level decreased in RA group, it increased in the control group(p<0.05). Irisin levels decreased in both groups. IL-6 level did not change in the control group, while it increased in RA group. A single exercise session had an acute anti-inflammatory effect in RA patients. Conclusion It can be concluded that acute aerobic exercise can be beneficial for patients with RA through cytokine, irisin, klotho and VEGF levels, and also it can be safely implemented to the RA rehabilitation program for additional anti-inflammatory effects. Trial registration ClinicalTrials.gov: NCT04439682
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    EFFECTS OF OBESITY ON THE SERUM BMP15, GDF9, AND KISSPEPTIN CONCENTRATIONS IN WOMEN OF REPRODUCTIVE AGE
    (Soc Medical Biochemists Serbia, 2023) Arikan, Funda Bulut; Sagsoz, Nevin
    Background: As BMP15, GDF9, and kisspeptin all play critical roles in folliculogenesis and fertilization, investigating the possible relationship between obesity and these three factors could prove crucial in relation to understanding the role of obesity in infertility. Thus, the present study sought to determine the effects of obesity on the serum BMP15, GDF9, and kisspeptin concentrations in women of reproductive age. Methods: Ninety female participants were equally divided into three groups: class-1 obese (n=30), class-2 obese (n=30), and normal weight (control; n=30). The participants' serum BMP15, GDF9, and AMH concentrations were measured. Moreover, the serum kisspeptin concentrations were evaluated in the class-1 obese and control groups by means of the enzyme-linked immunosorbent assay (ELISA) method while the participants were in their menstrual period. Results: The serum BMP15 and kisspeptin concentrations were found to be much higher in the control group than in both obese groups (p=0.001 and p=0.01, respectively). While the GDF9 concentration exhibited a statistically significant positive correlation with age, the BMP15 concentration exhibited a positive correlation with the kisspeptin and LH concentrations in the control group. In addition, a positive correlation was identified between the BMP15 concentration and both age and the glucose level and a negative correlation with the insulin level in both the obese groups. Conclusions: Obesity appears to reduce the serum BMP15 and kisspeptin concentrations in obese women of repro ductive age. This reduction may represent a milestone in reproductive dysfunction and may be used to predict the success of infertility treatment in obese women.
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    Investigation of the relationship between betatrophin and certain key enzymes involved in carbohydrate and lipid metabolism in insulin-resistant mice
    (Walter De Gruyter Gmbh, 2023) Arikan, Funda Bulut; Ulas, Mustafa; Ustundag, Yasemin; Boyunaga, Hakan; Badem, Nermin Dindar
    Objectives The present study sought to examine the relationship of betatrophin with certain key enzymes, namely lactate dehydrogenase-5 (LDH5), citrate synthase (CS), and acetyl-CoA carboxylase-1 (ACC1), in insulin-resistant mice.Methods Eight-week-old male C57BL6/J mice were used in this study (experimental group n=10 and control group n=10). S961 was administered using an osmotic pump to induce insulin resistance in the mice. The betatrophin, LDH5, CS, and ACC1 expression levels were determined from the livers of the mice using the real-time polymerase chain reaction (RT-PCR) method. Moreover, biochemical parameters such as the serum betatrophin, fasting glucose, insulin, triglyceride, total cholesterol, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were analyzed.Results The betatrophin expression and serum betatrophin (p=0.000), fasting glucose, insulin, triglyceride (p <= 0.001), and total cholesterol (p=0.013) levels were increased in the experimental group. In addition, the CS gene expression level was statistically significantly decreased in the experimental group (p=0.01). Although strong correlation was found between the expression and serum betatrophin and triglyceride levels, no correlation was found between the betatrophin gene expression and the LDH5, ACC1, and CS gene expression levels.Conclusions The betatrophin level appears to play an important role in the regulation of triglyceride metabolism, while insulin resistance increases both the betatrophin gene expression and serum levels and decreases the CS expression level. The findings suggest that betatrophin may not regulate carbohydrate metabolism through CS and LDH5 or lipid metabolism directly through the ACC1 enzyme.