Yazar "Arikan, O. K." seçeneğine göre listele

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    Effects of subjective tinnitus on sleep quality and mini mental status examination scores
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2010) Muluk, N. B.; Tuna, E.; Arikan, O. K.
    Objectives: We investigated the effects of subjective tinnitus on sleep quality and Mini Mental Status Examination (MMSE) scores of participants. Methods: The study group consisted of 15 patients, including 21 ears with tinnitus (6 bilateral, 9 unilateral). The control group consisted of 8 healthy patients with normal hearing and no tinnitus (16 ears). We assessed sleep quality using the Mini Sleep Questionnaire (MSQ) and mental health using the MMSE. Results: Sleep delay (SD) was significantly higher in tinnitus patients (5.28 +/- 2.23) compared to controls (3.25 +/- 2.56) (p = 0.018). Subjective tinnitus loudness level (STLL) scores were higher and sleep quality was impaired in females, older patients, and patients with lower MMSE scores. Sleep quality was also worse in patients with longer tinnitus duration. In younger and well educated patients, MMSE scores were higher. Higher STLL scores and shorter tinnitus duration were associated with lower MMSE scores. Patients with newly developed tinnitus reported more disturbances and showed greater effects on mental and cognitive functioning. Conclusion: In subjective tinnitus patients, sleep delay values increased. Long tinnitus duration and high STLL scores may affects patients' cognitive functions as shown by decreased MMSE scores. Furthermore, mental status changes in tinnitus patients were frequently overlooked.
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    Expressions of MMP2, MMP9, and TIMP-1 in the inflammatory cells of nasal polyps: granulocytes, monocytes, and mast cells
    (Verduci Publisher, 2023) Muluk, N. Bayar; Arikan, O. K.; Atasoy, P.; Kilic, R.; Yalcinozan, E. Tuna
    OBJECTIVE: We investigated the role of matrix metalloproteinase-2 (MMP-2) and MMP-9 in nasal polyp (NP) pathogenesis. PATIENTS AND METHODS: In group 1 (n = 24), polyp specimens were obtained from maxillary sinus, ethmoid sinus, and nasal cavity. In group 2 without NP (control) (n = 11), inferior turbinate samples were taken. Inflammatory cell count and MMP2, MMP9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1), positivity indexes (PIs) were evaluated. RESULTS: Granulocyte and mast cell-MMP2 and MMP9-PI were higher than the rate of monocyte-MMP2-PI and monocyte-MMP9-PI, respectively, in the ethmoid sinus, maxillary sinus, and nasal cavity. Mast Cell-TIMP1-PI was higher than the rates of granulocyte-TIMP1-PI and monocyte-TIMP1-PI in the maxillary sinus and was higher than the rate of monocyte-TIMP1-PI in the ethmoid sinus. CONCLUSIONS: Excessive MMP2 and MMP9, compared to TIMP1, are present in granulocytes and mast cells, respectively. With matrix MMPs, the extracellular matrix is destroyed, leading inflammatory cells to pass through, causing polypoid degeneration.
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    Inducible nitric oxide synthase (iNOS) in sinonasal polyp pathogenesis
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2013) Muluk, N. Bayar; Arikan, O. K.; Atasoy, P.; Kilic, R.; Yalcinozan, E. Tuna
    Objectives: We investigated the role of inducible nitric oxide synthase (iNOS) in the pathogenesis of sinonasal polyps. Methods: Adult patients (21 men, 3 women) with nasal polyposis underwent functional endoscopic sinus surgery. Nine adults without polyps (6 men) who underwent septoplasty and/or rhinoplasty served as controls. Polyp specimens came from three regions: the maxillary sinus (10), ethmoid sinus (14), and nasal cavity (10). Control group samples (9) came from the inferior turbinate. Specimens were evaluated in eight mucosal layers for count and distribution of inflammatory cells and iNOS expression. An iNOS positivity index (PI) was determined for the epithelium (E), subepithelial layer of the lamina propria (SE), and deep paraglandular layer of the mucosa (D). Results: Polymorphonuclear cell (PMNC) % values of the ethmoid and maxillary sinus and overall ethmoid sinus PI were significantly higher in the polyp group. Patients with longer polyp duration, D-perivascular (D-pv), and a higher Brinkmann index had decreased ethmoid sinus D Pis. However, in older patients and patients with longer polyp duration, perivascular PIs increased in maxillary sinus SE and D, respectively. Furthermore, as PMNC % and iNOS-PMNC PI increased, SE_glandular and epithelial_apical iNOS values decreased. In the ethmoid and maxillary sinuses, iNOS_D_endothelial values increased but decreased in the nasal cavity. Conclusions: iNOS may play a role in sinonasal polyp pathogenesis, especially in mucosal SE and D layers. Increased vascular permeability, stromal edema, inflammatory cell migration into the stroma of the mucosa, and increased mucosal gland secretion may result in polyp formation.
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    Is there any correlation between chronic noise-induced hearing loss and mastoid pneumatization volume? A preliminary study
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2012) Cirpar, O.; Arikan, O. K.; Kendi, T.; Gorgulu, O.
    Is there any correlation between chronic noise-induced hearing loss and mastoid pneumatization volume? A preliminary study. Objectives: To investigate the possible association between chronic noise-induced hearing loss and the volume of mastoid pneumatization. Methodology: The study involved 46 subjects employed in the press and montage department of a gun factory: 28 in the study group with noise-induced hearing loss and 18 in the control group with no hearing loss. The volume of mastoid pneumatization was measured with computed tomography. Student's test was used in the comparison of the mastoid volumes of the study and the control groups. Results: The intergroup evaluations showed no significant difference between the study and control group with regards to age, use of substances or ototoxic drugs, systemic diseases, use of personal hearing protectors, duration of occupational and non-occupational noise exposure was observed (P > 0.05). The mean values of mastoid pneumatization in the study and the control groups were 9717.6 mm(3) and 11005.8 mm(3), respectively. Although the volume of mastoid pneumatization was smaller in the study group than in the control group, this difference was not statistically significant (P > 0.05). Conclusions: This preliminary study showed that there was no significant correlation between mastoid pneumatization volume and chronic noise-induced hearing loss. However, this correlation could be significant in further studies with a larger number of subjects.
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    Olfactory bulb volume and olfactory sulcus depth in patients with Behcet's disease
    (Cambridge Univ Press, 2018) Dogan, A.; Muluk, N. Bayar; Asal, N.; Sahan, m H.; Inal, M.; Gunduz, O; Arikan, O. K.
    Objective To investigate olfactory bulb volume and olfactory sulcus depth in patients with Behcet's disease, using magnetic resonance imaging. Methods Cranial magnetic resonance imaging scans of 27 adults with Behcet's disease (10 males and 17 females) and 27 healthy controls were examined. Olfactory bulb volume and olfactory sulcus depth were measured on coronal, T2-weighted, spectral pre-saturation with inversion recovery sequences. Results Bilateral olfactory bulb volume and right-sided olfactory sulcus depth were significantly lower in the Behcet's disease group than in the control group (p < 0.05). Left-sided olfactory sulcus depth increased with Behcet's disease duration. In both groups, olfactory bulb volume was significantly higher in the left than the right side. There were no gender differences for olfactory bulb volume and olfactory sulcus depth. Positive correlations were determined between right- and left-sided olfactory bulb volume values and between right- and left-sided olfactory sulcus depth values. Conclusion Behcet's disease may decrease olfactory functions, related to lower olfactory bulb volume and olfactory sulcus depth. The affected vascular system and possibly damaged neural system, nasal mucosal lesions, and prolonged nasal mucociliary clearance time may cause olfactory dysfunction. Patient follow up is recommended, with magnetic resonance imaging examinations of the olfactory system if necessary.
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    Treatment of rhinophyma with radiofrequency: a case report
    (Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2010) Arikan, O. K.; Muluk, Nuray Bayar; Cirpar, O.
    Treatment of rhinophyma with radiofrequency: a case report. Problem: Rhinophyma is characterized by a slow progressive enlargement of the nasal skin that cannot resolve spontaneously. Clinically, the lower two-thirds of the nose becomes enlarged and hypervascular, developing a reddish-purple discoloration and a nodular appearance. It is believed that rhinophyma represents the end stage of acne rosacea. The treatment modalities are medical and surgical. Case: This study describes a 62-year-old man with rhinophyma that was treated with a radiofrequency technique. The pathological examination was compatible with acne rosacea. After surgery, a broad-spectrum sunscreen was applied until reepithelialization was complete. Conclusion: We recommend the radiofrequency technique for treatment of rhinophyma.