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    Thyroid Autoimmunity may Affect Mean Platelet Volume
    (Gazi Univ, Fac Med, 2022) Sari, Isilay Kalan; Arikan, Senay; Yavuz, Seyma; Carlioglu, Ayse
    Objective: Mean platelet volume (MPV) has been associated with autoimmune diseases and is considered a potentially useful parameter to assess platelet activity and subclinical inflammation. In the present study, we aimed to investigate the effects of thyroid autoimmunity on MPV. Methods: 84 patients with newly diagnosed Hashimoto's thyroiditis (HT), including 44 euthyroid (EHT, mean age 41.4 +/- 10.8 years) and 40 hypothyroid (HHT, mean age 44.6 +/- 13.2 years) patients, 61 patients with newly diagnosed Graves' disease (GD, mean age 42.8 +/- 12.4 years) and 57 euthyroid control subjects (age-matched 46.4 +/- 11.6 years) were included in the study. Patients were not taking antithyroid medication or levothyroxine. Thyroid hormones and platelet parameters were determined in all study participants. Results: The MPV of the patients was significantly higher than that of the control group (p:0.008). There was no association between MPV and age, sex, or TSH (p:0.06, p:0.4, and p:0.9, respectively). MPV increased in chronic autoimmune thyroid disease regardless of age, sex, and TSH. Conclusion: Our results suggest that autoimmunity, rather than thyroid hormone levels, affects MPV in GD and HT.
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    Ultrasound Elastography of the Median Nerve in Patients With Acromegaly: A Case-Control Study
    (Wiley, 2018) Burulday, Veysel; Dogan, Adil; Sahan, Mehmet Hamdi; Arikan, Senay; Gungunes, Askin
    Objectives The aim of this study was to compare the cross-sectional area and ultrasound elastographic findings of the median nerve of patients with acromegaly and healthy participants. Methods The acromegaly group comprised 15 patients with a previous diagnosis of acromegaly, and an age- and sex-matched control group included healthy participants. Strain elastographic and shear wave elastographic findings and the cross-sectional areas of the groups were compared. A 6-15-MHz multifrequency transducer was used for ultrasound evaluations. Results A total of 30 hands of 15 patients with acromegaly (7 male and 8 female) with a mean ageSD of 50.00 +/- 10.17 years and 40 hands of 20 healthy control participants (9 male and 11 female) with a mean age of 49.50 +/- 10.17 years were taken into consideration for statistical analyses. The cross-sectional area of the patients with acromegaly was significantly higher than that of the healthy controls (13.43 +/- 3.12 versus 8.32 +/- 1.94mm(2); P<.05). Median nerve stiffness was significantly increased in the acromegaly group compared with the control group (axial and longitudinal, 37.15 +/- 6.4 and 37.0 +/- 6.19 versus 18.7 +/- 4.1 and 19.2 +/- 3.58 kPa, respectively; P<.001). Conclusions These preliminary results have demonstrated that patients with acromegaly seem to have increased stiffness and cross-sectional area of the median nerve compared with healthy participants.