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  • Küçük Resim
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    Effect of alprostadil on erythrocyte deformability in ischemia reperfusion injury
    (Comenius Univ, 2015) Kara, H.; Ozer, A.; Arpaci, H.; Demirtas, H.; Comu, F. M.; Oktar, G. L.; Arslan, M.
    BACKGROUND: Ischemia reperfusion injury (I/R) in lower extremity is a frequent and important clinical phenomenon. Protective effect of alprostadil on local and distant organ injury due to I/R has been well-documented but its effect on erythrocyte deformability needs further investigation. Our aim was to investigate the effect of alprostadil on erythrocyte deformability in infrarenal aorta of rats undergoing I/R. MATERIALS AND METHODS: Our study was conducted with 18 Wistar albino rats. Rats were divided into 3 groups; randomized control group (group C; n = 6), I/R group without alprostadil (group I/R; n = 6) and I/R group with alprostadil 20 mcg.kg(-1), intraperitoneal (group IR-A; n = 6). Packs of erythrocytes were prepared from heparinized blood samples and deformability measurements were done. RESULTS: Comparisons of the control and IR-A groups revealed similar results (p = 0.240). The values of the IR group were significantly higher than those of the control and IR-A groups (p = 0.009, p = 0.026, respectively). CONCLUSION: In our study, we detected unfavourable effects of I/R on erythrocyte deformability, which may lead to disturbance in blood flow and hence tissue perfusion in infrarenal rat aorta. We also found that alprostadil had beneficial effects by reversing undesirable effects of I/R (Fig. 1, Ref. 22). Text in PDF www.elis.sk.
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    Vitamin C ameliorates high dose Dexmedetomidine induced liver injury
    (Comenius Univ, 2016) Arslan, M.; Sezen, S. C.; Turgut, H. C.; Kocabiyik, M.; Arpaci, H.; Comu, F. M.; Kavutcu, M.
    BACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCI intraperitoneally (ip), Dexmedetomidine 5 mu g.kg(-1) (ip), Dexmedetomidine 5 mu g.kg(-1) ip plus Vitamin C (100 mng.kg(-1)), Dexmedetomidine 10 mu g.kg(-1) ip and Dexmedetomidine 10 mu g.kg(-1) ip plus Vitamin C (100 mg.kg-1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30). Text in PDF www.elis.sk.