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Öğe Buerger's disease with multisystem involvement: A case report and a review of the literature(2004) Çalgüneri, Meral; Öztürk, Mehmet Akif; Ay, Hakan; Arsava, Ethem M.; Altinok, Deniz; Ertenli, İhsan; Kiraz, SedatBuerger's disease is a recurrent inflammatory, nonatherosclerotic vasoocclusive disease, which typically affects small and medium-sized arteries, veins, and nerves of the upper and lower extremities. Systemic manifestations involving cerebral, mesenteric, and coronary arteries are exceptional. Moreover, multisystem involvement of 2 or more organs is extremely rare. The authors present a case of Buerger's disease in a patient who subsequently developed cerebral and bowel infarcts as well as cavernomatous transformation of the portal vein. Therefore, Buerger's disease, although rare, does have a chronic aggressive nature in some patients.